sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5e72 | SAM | N2, N2-dimethylguanosine tRNA methyltransferase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 5e72 | SAM | N2, N2-dimethylguanosine tRNA methyltransferase | / | 1.000 | |
| 3qv2 | SAH | 5-cytosine DNA methyltransferase | / | 0.519 | |
| 2zif | SAM | Methyltransferase | / | 0.518 | |
| 2eg5 | SAH | 7-methylxanthosine synthase 1 | / | 0.512 | |
| 3pt9 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.507 | |
| 4wxx | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.506 | |
| 1boo | SAH | Modification methylase PvuII | 2.1.1.113 | 0.501 | |
| 3sr4 | TT8 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.501 | |
| 2ore | SAH | DNA adenine methylase | 2.1.1.72 | 0.500 | |
| 1g38 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.492 | |
| 4u7t | SAH | DNA (cytosine-5)-methyltransferase 3A | 2.1.1.37 | 0.492 | |
| 3ldf | SAH | Uncharacterized protein | / | 0.491 | |
| 2np7 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.490 | |
| 3swr | SFG | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.490 | |
| 4h0n | SAH | Dnmt2 | / | 0.488 | |
| 3nu3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.486 | |
| 4rtr | SAM | DNA adenine methylase | 2.1.1.72 | 0.484 | |
| 1nv8 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.483 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.482 | |
| 1dif | A85 | Gag-Pol polyprotein | / | 0.480 | |
| 3upj | U03 | Gag-Pol polyprotein | / | 0.480 | |
| 4iv8 | SAM | Phosphoethanolamine N-methyltransferase,putative | / | 0.480 | |
| 1sg9 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.478 | |
| 1skm | SAH | Modification methylase HhaI | 2.1.1.37 | 0.478 | |
| 3pt6 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.478 | |
| 4rtl | SFG | DNA adenine methylase | 2.1.1.72 | 0.478 | |
| 1qbu | 846 | Gag-Pol polyprotein | 3.4.23.16 | 0.477 | |
| 1r00 | SAH | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.477 | |
| 4mwz | SAM | Phosphoethanolamine N-methyltransferase, putative | / | 0.477 | |
| 4onq | SFG | DNA methyltransferase | / | 0.477 | |
| 5e8j | SAH | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.476 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.475 | |
| 2gd2 | CAA | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.475 | |
| 2ih2 | NEA | Modification methylase TaqI | 2.1.1.72 | 0.474 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.474 | |
| 3s43 | 478 | Protease | / | 0.474 | |
| 4da4 | SAH | DNA (cytosine-5)-methyltransferase 1 | 2.1.1.37 | 0.473 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.472 | |
| 3ldg | SAH | Uncharacterized protein | / | 0.472 | |
| 3lst | SAH | CalO1 | / | 0.472 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.472 | |
| 3dcr | KVS | Protease | / | 0.471 | |
| 4fr0 | SAM | Arsenic methyltransferase | / | 0.471 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.471 | |
| 8mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.471 | |
| 3a25 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.470 | |
| 3kq7 | KQ7 | Mitogen-activated protein kinase 14 | / | 0.470 | |
| 4hdp | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.470 | |
| 1w5v | BE3 | Gag-Pol polyprotein | 3.4.23.16 | 0.469 | |
| 3nu5 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.469 | |
| 4blw | SAH | Ribosomal RNA large subunit methyltransferase J | / | 0.469 | |
| 1ivq | 0PX | Gag-Pol polyprotein | / | 0.468 | |
| 3djk | G55 | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 1hvr | XK2 | Gag-Pol polyprotein | / | 0.467 | |
| 5mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.467 | |
| 1npa | 3NH | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
| 1npw | LGZ | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
| 2upj | U02 | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
| 1d4j | MSC | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 1qzz | SAM | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.465 | |
| 1t7k | BH0 | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 3s54 | 017 | Protease | / | 0.465 | |
| 2bpv | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 3uj7 | SAM | Phosphoethanolamine N-methyltransferase | / | 0.464 | |
| 5fa8 | SAM | Ribosomal protein L11 methyltransferase, putative | / | 0.464 | |
| 10mh | SAH | Modification methylase HhaI | 2.1.1.37 | 0.463 | |
| 1g35 | AHF | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 1hpo | UNI | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 1dw6 | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 2j3i | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.462 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 2qak | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.462 | |
| 3lby | SAH | Uncharacterized protein | / | 0.462 | |
| 3v97 | SAH | Ribosomal RNA large subunit methyltransferase K/L | 2.1.1.173 | 0.462 | |
| 3vfa | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
| 1bv7 | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 1rd4 | L08 | Integrin alpha-L | / | 0.461 | |
| 2fxe | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 3gi6 | D78 | Gag-Pol polyprotein | / | 0.461 | |
| 1nv9 | SAH | Release factor glutamine methyltransferase | 2.1.1.297 | 0.460 | |
| 2b7z | MK1 | Gag-Pol polyprotein | / | 0.460 | |
| 2fde | 385 | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.460 | |
| 4rtp | SAM | DNA adenine methylase | 2.1.1.72 | 0.460 | |
| 6upj | NIU | Gag-Pol polyprotein | / | 0.460 | |
| 1vq1 | SAM | Release factor glutamine methyltransferase | 2.1.1.297 | 0.459 | |
| 2qd8 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 3kfr | 3TL | Gag-Pol polyprotein | / | 0.459 | |
| 3lzu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 3own | 3OW | Renin | 3.4.23.15 | 0.459 | |
| 1ec3 | MS3 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.458 | |
| 2pqz | G0G | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 2r5q | 1UN | Gag-Pol polyprotein | / | 0.458 | |
| 3ndw | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 4j55 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 1fff | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 1hvs | A77 | Gag-Pol polyprotein | / | 0.457 | |
| 2aqu | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 2bb9 | AKC | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 2qd7 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 3ekw | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 9mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.457 | |
| 2i4x | KGQ | Protease | / | 0.456 | |
| 2q64 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 2zwv | SAH | Probable ribosomal RNA small subunit methyltransferase | / | 0.456 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.456 | |
| 3nuj | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 4j5j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.456 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.456 | |
| 4qtu | SAM | 18S rRNA (guanine(1575)-N(7))-methyltransferase | / | 0.456 | |
| 4rtj | SFG | DNA adenine methylase | 2.1.1.72 | 0.456 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 2fdd | 385 | Pol protein | / | 0.455 | |
| 2g1p | SAH | DNA adenine methylase | 2.1.1.72 | 0.455 | |
| 2p3b | 3TL | V-1 PROTEASE protein | / | 0.455 | |
| 2p3b | 3TL | V-1 protease | / | 0.455 | |
| 2qe6 | SAM | Uncharacterized protein | / | 0.455 | |
| 3ckt | YDP | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3el5 | 1UN | Gag-Pol polyprotein | / | 0.455 | |
| 4djy | 0KR | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 1msm | JE2 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 1ody | LP1 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 1wbm | BLL | Pol protein | / | 0.454 | |
| 2hs1 | 017 | Protease | / | 0.454 | |
| 2r5p | MK1 | Gag-Pol polyprotein | / | 0.454 | |
| 3bgb | LJG | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.454 | |
| 3jvw | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3lzv | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3qrs | NK8 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 4upj | U04 | Gag-Pol polyprotein | / | 0.454 | |
| 1yt9 | OIS | Gag-Pol polyprotein | / | 0.453 | |
| 2fxd | DR7 | Pol polyprotein | / | 0.453 | |
| 3grr | SAH | Probable ribosomal RNA small subunit methyltransferase A | / | 0.453 | |
| 3nu4 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3nuo | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 3ttp | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 1bve | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 1idb | 0DO | Gag-Pol polyprotein | / | 0.452 | |
| 2ibt | NEA | Modification methylase TaqI | 2.1.1.72 | 0.452 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.452 | |
| 2yx1 | SFG | tRNA (guanine(37)-N1)-methyltransferase Trm5b | 2.1.1.228 | 0.452 | |
| 3bgc | LJH | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 4a6c | QG9 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 4gxs | 0YS | Glutamate receptor 2 | / | 0.452 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.452 | |
| 4ylf | FAD | Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit homolog | / | 0.452 | |
| 1bwb | 146 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.451 | |
| 1t7i | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 1wbk | 568 | Pol protein | / | 0.451 | |
| 2dpm | SAM | Modification methylase DpnIIA | 2.1.1.72 | 0.451 | |
| 2hs2 | 017 | Protease | / | 0.451 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.451 | |
| 3ndx | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3o9a | K14 | Pol polyprotein | / | 0.451 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.451 | |
| 4l4x | NDP | AmphI | / | 0.451 | |
| 4rtm | SAM | DNA adenine methylase | 2.1.1.72 | 0.451 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.450 | |
| 2bpy | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2hmy | SAM | Modification methylase HhaI | 2.1.1.37 | 0.450 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.450 | |
| 3f6s | FMN | Flavodoxin | / | 0.450 | |
| 3kdd | JZQ | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 3p9k | SAH | Caffeic acid O-methyltransferase | / | 0.450 | |
| 3vf5 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 4j54 | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 4obw | SAM | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial | / | 0.450 | |
| 5ccb | SAH | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A | 2.1.1.220 | 0.450 | |
| 2bpz | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2hv9 | SFG | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.449 | |
| 2qci | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 2tct | CTC | Tetracycline repressor protein class D | / | 0.449 | |
| 3vfb | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 1bwa | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1gth | FAD | Dihydropyrimidine dehydrogenase [NADP(+)] | 1.3.1.2 | 0.448 | |
| 1hii | C20 | Gag-Pol polyprotein | / | 0.448 | |
| 1qbt | 146 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1z1r | HBH | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 2cej | 1AH | Pol protein | / | 0.448 | |
| 2hfp | NSI | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 2qi7 | MZ9 | Gag-Pol polyprotein | / | 0.448 | |
| 2wpx | ACO | Orf14 | / | 0.448 | |
| 3tr6 | SAH | O-methyltransferase | / | 0.448 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 5je3 | SAH | Methyl transferase | / | 0.448 | |
| 1fjx | SAH | Modification methylase HhaI | 2.1.1.37 | 0.447 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1mes | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2yim | MC4 | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.447 | |
| 3a9w | NAD | NDP-sugar epimerase | / | 0.447 | |
| 3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3egv | SAH | Ribosomal protein L11 methyltransferase | 2.1.1 | 0.447 | |
| 3el4 | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 3lga | SAH | tRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI | 2.1.1.219 | 0.447 | |
| 4fp9 | SAM | 5-methylcytosine rRNA methyltransferase NSUN4 | 2.1.1 | 0.447 | |
| 4onj | SFG | DNA methyltransferase | / | 0.447 | |
| 5epe | SAH | Uncharacterized protein | / | 0.447 | |
| 5hi2 | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.447 | |
| 1d4k | PI8 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1hsh | MK1 | Gag-Pol polyprotein | / | 0.446 | |
| 1l3i | SAH | Probable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) | / | 0.446 | |
| 2idw | 017 | Protease | / | 0.446 | |
| 2ieo | 017 | Protease | / | 0.446 | |
| 2nu9 | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.446 | |
| 2qd6 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3gi4 | K60 | Gag-Pol polyprotein | / | 0.446 | |
| 3imx | B84 | Glucokinase | 2.7.1.2 | 0.446 | |
| 3uhl | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1ff0 | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 1qbs | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1w5y | BE6 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1xl5 | 190 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2bqv | A1A | Protease | / | 0.445 | |
| 2cdu | FAD | NADH oxidase | / | 0.445 | |
| 2j3k | NAP | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.445 | |
| 2pyn | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 2y3r | TIR | TamL | / | 0.445 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.445 | |
| 3hzc | 2NC | Protease | / | 0.445 | |
| 3i7e | DJR | Gag-Pol polyprotein | / | 0.445 | |
| 3mws | 017 | Pol protein | / | 0.445 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.445 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.445 | |
| 4a4q | UX9 | Pol protein | / | 0.445 | |
| 4q1y | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 7mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.445 | |
| 1c70 | L75 | Protease | / | 0.444 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.444 | |
| 1rbm | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.444 | |
| 1sbg | IM1 | Gag-Pol polyprotein | / | 0.444 | |
| 1wc4 | APC | Adenylate cyclase | / | 0.444 | |
| 2c3q | GTX | Glutathione S-transferase theta-1 | 2.5.1.18 | 0.444 | |
| 2gd0 | MRS | Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase ) | / | 0.444 | |
| 2qnp | QN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.444 | |
| 3d1z | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3qw2 | NAD | Myo-inositol-1-phosphate synthase (Ino1) | / | 0.444 | |
| 3s1s | SAH | Restriction endonuclease BpuSI | / | 0.444 | |
| 3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.444 | |
| 3zps | EQM | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 4c04 | SFG | Protein arginine N-methyltransferase 6 | / | 0.444 | |
| 4dqh | 017 | Gag-Pol polyprotein | / | 0.444 | |
| 4h3i | 10V | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4rtn | SAH | DNA adenine methylase | 2.1.1.72 | 0.444 | |
| 1c6z | ROC | Protease | / | 0.443 | |
| 3d1y | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3ekx | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3em3 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3liq | E14 | Protease | / | 0.443 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.443 | |
| 4r6x | SAH | Phosphoethanolamine N-methyltransferase | / | 0.443 | |
| 4rts | SAM | DNA adenine methylase | 2.1.1.72 | 0.443 | |
| 4z26 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.443 | |
| 1b6p | PI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.442 | |
| 1jld | 0PP | Gag-Pol polyprotein | / | 0.442 | |
| 1nw3 | SAM | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.442 | |
| 1rl8 | RIT | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1siv | PSI | Gag-Pol polyprotein | / | 0.442 | |
| 2fdp | FRP | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2nxe | SAM | Ribosomal protein L11 methyltransferase | 2.1.1 | 0.442 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.442 | |
| 2q61 | SF1 | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.442 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.442 | |
| 3liv | E16 | Protease | / | 0.442 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.442 | |
| 3tm4 | SAM | Uncharacterized protein | / | 0.442 | |
| 4djp | M73 | Pol polyprotein | / | 0.442 | |
| 4kb9 | G79 | Protease | / | 0.442 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.442 | |
| 4qgi | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 4rto | SFG | DNA adenine methylase | 2.1.1.72 | 0.442 | |
| 1d4i | BEG | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1d4l | PI9 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1zsr | 0ZT | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2f80 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2r3t | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3dmh | SAM | Probable ribosomal RNA small subunit methyltransferase | / | 0.441 | |
| 3em6 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4djr | 0KJ | Pol polyprotein | / | 0.441 | |
| 4gbe | SAH | DNA adenine methylase | 2.1.1.72 | 0.441 | |
| 4hdf | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.441 | |
| 4oj4 | DIF | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.440 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.440 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.440 | |
| 1rc0 | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.440 | |
| 2f8l | SAM | Lmo1582 protein | / | 0.440 | |
| 2uxz | HI1 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3f46 | I2C | 5,10-methenyltetrahydromethanopterin hydrogenase | 1.12.98.2 | 0.440 | |
| 3gc9 | B45 | Mitogen-activated protein kinase 11 | 2.7.11.24 | 0.440 | |
| 3ok9 | G52 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3sa9 | A68 | Protease | / | 0.440 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 4oa5 | SAH | O-methyltransferase family protein | / | 0.440 | |
| 5c46 | GSP | Ras-related protein Rab-11A | / | 0.440 |