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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5cuqNSCGenome polyprotein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5cuqNSCGenome polyprotein/1.000
3p8zSAHGenome polyprotein2.1.1.560.585
3evaSAHGenome polyprotein2.1.1.560.551
3evbSAHGenome polyprotein2.1.1.560.550
4k6mSAHGenome polyprotein/0.528
2p3qSAHGenome polyprotein/0.505
3evcSAHGenome polyprotein2.1.1.560.501
3p97SAMGenome polyprotein2.1.1.560.493
5jjrSAHGenome polyprotein/0.483
2x06NADL-sulfolactate dehydrogenase/0.482
2p41SAHGenome polyprotein/0.481
2pxaSAHGenome polyprotein2.7.7.480.479
1l9kSAHGenome polyprotein2.7.7.480.477
5dtoSAHGenome polyprotein/0.473
3fhxPLPPyridoxal kinase2.7.1.350.472
4bfvZVVPantothenate kinase2.7.1.330.466
2bfaCB3Pteridine reductase 11.5.1.330.465
4bfxZVXPantothenate kinase2.7.1.330.464
1ay0TPPTransketolase 12.2.1.10.460
1vbiNADMalate/L-lactate dehydrogenase family protein/0.460
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.458
1obnASVIsopenicillin N synthase1.21.3.10.454
4ctjSAMGenome polyprotein/0.454
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.454
2oxnOANBeta-hexosaminidase/0.453
3p8z36AGenome polyprotein2.1.1.560.453
4ho6UTPGlucose-1-phosphate thymidylyltransferase/0.453
4iix1EGMicrocin C7 self-immunity protein MccF/0.452
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
3zhrTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.451
4zj8SUVOrexin receptor type 1/0.451
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.450
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.450
3pe2E1BCasein kinase II subunit alpha2.7.11.10.450
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.448
4bb3KKAIsopenicillin N synthase1.21.3.10.448
2zbaZBATrichothecene 3-O-acetyltransferase/0.447
2g8yNADHydroxycarboxylate dehydrogenase B/0.446
2p1dSAHGenome polyprotein2.7.7.480.446
3qiyQI1Botulinum neurotoxin type A3.4.24.690.446
4bfsZVSPantothenate kinase2.7.1.330.446
2y60M8FIsopenicillin N synthase1.21.3.10.445
4ipw1G7Mycocyclosin synthase1.14.21.90.443
5jjsSAHGenome polyprotein/0.443
1cq8PY6Aspartate aminotransferase2.6.1.10.442
1f4fTP3Thymidylate synthase/0.442
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.441
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.441
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3zoiM2WIsopenicillin N synthase1.21.3.10.441
4bfwZVWPantothenate kinase2.7.1.330.441
1l8qADPChromosomal replication initiator protein DnaA/0.440
1oc1ASVIsopenicillin N synthase1.21.3.10.440
1r6aSAHGenome polyprotein2.7.7.480.440
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.440