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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5cccDDFDihydrofolate reductase1.5.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5cccDDFDihydrofolate reductase1.5.1.31.000
1rf7DHFDihydrofolate reductase1.5.1.30.566
1rx5DDFDihydrofolate reductase1.5.1.30.555
4ej1FOLDihydrofolate reductase1.5.1.30.540
3eigMTXDihydrofolate reductase1.5.1.30.536
1ddsMTXDihydrofolate reductase1.5.1.30.533
1dyhDZFDihydrofolate reductase1.5.1.30.526
4i13FOLDihydrofolate reductase1.5.1.30.526
5cc9DDFDihydrofolate reductase1.5.1.30.526
1rx7FOLDihydrofolate reductase1.5.1.30.524
1jomFFODihydrofolate reductase1.5.1.30.523
4cd2FOLDihydrofolate reductase1.5.1.30.522
1re7FOLDihydrofolate reductase1.5.1.30.521
4i1nFOLDihydrofolate reductase1.5.1.30.515
1rx8FOLDihydrofolate reductase1.5.1.30.512
1rb3MTXDihydrofolate reductase1.5.1.30.511
1draMTXDihydrofolate reductase1.5.1.30.510
1drbMTXDihydrofolate reductase1.5.1.30.509
1ddrMTXDihydrofolate reductase1.5.1.30.508
3drcMTXDihydrofolate reductase1.5.1.30.508
3och2MXDihydrofolate reductase1.5.1.30.508
1dhjMTXDihydrofolate reductase1.5.1.30.507
1rc4DDFDihydrofolate reductase1.5.1.30.507
1rb2FOLDihydrofolate reductase1.5.1.30.506
2drcMTXDihydrofolate reductase1.5.1.30.506
2dhfDZFDihydrofolate reductase1.5.1.30.505
4dfrMTXDihydrofolate reductase1.5.1.30.505
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.502
1jolFFODihydrofolate reductase1.5.1.30.501
1dyjDDFDihydrofolate reductase1.5.1.30.500
1tdrMTXDihydrofolate reductase1.5.1.30.497
4o761M3Bromodomain-containing protein 4/0.491
1ia3TQ5Dihydrofolate reductase1.5.1.30.490
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.490
4xe606UDihydrofolate reductase1.5.1.30.490
4x5jFOLDihydrofolate reductase1.5.1.30.489
2d0kFOLDihydrofolate reductase1.5.1.30.488
4ele31IDihydrofolate reductase/0.487
1dyiFOLDihydrofolate reductase1.5.1.30.486
1rd7FOLDihydrofolate reductase1.5.1.30.485
3oafOAGDihydrofolate reductase1.5.1.30.484
4x5iFOLDihydrofolate reductase1.5.1.30.484
5hi6MTXDihydrofolate reductase/0.478
1dhiMTXDihydrofolate reductase1.5.1.30.477
1rx6DDFDihydrofolate reductase1.5.1.30.474
1ia4TQ6Dihydrofolate reductase1.5.1.30.470
4elb34SDihydrofolate reductase/0.469
3fl8RARDihydrofolate reductase/0.468
4elb34RDihydrofolate reductase/0.468
3sh25DRDihydrofolate reductase1.5.1.30.467
1dr3HBIDihydrofolate reductase1.5.1.30.464
1ra8FOLDihydrofolate reductase1.5.1.30.464
4h9814QUncharacterized protein/0.463
1diuBDMDihydrofolate reductase1.5.1.30.461
1ao8MTXDihydrofolate reductase1.5.1.30.459
3sai9DRDihydrofolate reductase/0.459
2cig1DGDihydrofolate reductase1.5.1.30.458
2jn3JN3Fatty acid-binding protein, liver/0.458
3qg2CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.458
4a9iP9IBromodomain-containing protein 2/0.458
4h9614QDihydrofolate reductase1.5.1.30.458
1rx4DDFDihydrofolate reductase1.5.1.30.457
1j3iWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
2qk8MTXDihydrofolate reductase/0.455
3jwm5WBDihydrofolate reductase/0.455
4a9mP9MBromodomain-containing protein 2/0.454
4z07PCGcGMP-dependent protein kinase 12.7.11.120.454
3s3vTOPDihydrofolate reductase1.5.1.30.453
2wi72KLHeat shock protein HSP 90-alpha/0.452
1klkPMDDihydrofolate reductase1.5.1.30.451
4elg52JDihydrofolate reductase/0.451
1aoeGW3Dihydrofolate reductase1.5.1.30.450
3l0lHC3Nuclear receptor ROR-gamma/0.450
4dpdDHFBifunctional dihydrofolate reductase-thymidylate synthase/0.450
1uy8PU5Heat shock protein HSP 90-alpha/0.449
3qly55VUncharacterized protein/0.448
4fgg0U5Dihydrofolate reductase1.5.1.30.448
1h2bNAJNAD-dependent alcohol dehydrogenase/0.447
3qlzQLZUncharacterized protein/0.447
1vj3TABDihydrofolate reductase1.5.1.30.446
3mg3ECHOrange carotenoid-binding protein/0.446
3qfxCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.446
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
1bwsNDPGDP-L-fucose synthase/0.445
1bzfTMQDihydrofolate reductase1.5.1.30.445
3cseN22Uncharacterized protein/0.445
3eek53SUncharacterized protein/0.445
1disBDMDihydrofolate reductase1.5.1.30.444
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.444
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4g95OAGDihydrofolate reductase1.5.1.30.444
4h9506UDihydrofolate reductase1.5.1.30.444
4nb6444Nuclear receptor ROR-gamma/0.444
1fmjRTLRetinol dehydratase/0.443
2cd2FOLDihydrofolate reductase1.5.1.30.443
1cd2FOLDihydrofolate reductase1.5.1.30.442
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1s3vTQDDihydrofolate reductase1.5.1.30.442
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.442
3qgtCP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.441
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4g47TZFMycocyclosin synthase1.14.21.90.441
4qi9MTXDihydrofolate reductase/0.441
2zb45OPProstaglandin reductase 21.3.1.480.440
3vt9YI4Vitamin D3 receptor/0.440
4h9753SDihydrofolate reductase1.5.1.30.440