scPDB - Distribution of Binding site Similarity values of 5cc9 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
5cc9	DDF	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
5cc9	DDF	Dihydrofolate reductase	1.5.1.3	1.000
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.552
1jom	FFO	Dihydrofolate reductase	1.5.1.3	0.528
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.519
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.512
2dhf	DZF	Dihydrofolate reductase	1.5.1.3	0.504
1dhf	FOL	Dihydrofolate reductase	1.5.1.3	0.495
1drf	FOL	Dihydrofolate reductase	1.5.1.3	0.495
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.494
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.493
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.490
1s3u	TQD	Dihydrofolate reductase	1.5.1.3	0.489
4zzi	1NS	NAD-dependent protein deacetylase sirtuin-1	3.5.1	0.488
3s3v	TOP	Dihydrofolate reductase	1.5.1.3	0.487
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.486
1dr3	HBI	Dihydrofolate reductase	1.5.1.3	0.483
1pd9	CO4	Dihydrofolate reductase	1.5.1.3	0.482
3w6h	AZM	Carbonic anhydrase 1	4.2.1.1	0.474
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.470
1pkf	EPD	Epothilone C/D epoxidase	1.14	0.470
2d0k	FOL	Dihydrofolate reductase	1.5.1.3	0.469
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.468
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.467
4rlh	0WE	Enoyl-[acyl-carrier-protein] reductase [NADH]	/	0.467
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.467
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.465
3n5w	XFJ	Nitric oxide synthase, brain	1.14.13.39	0.463
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.460
1q5d	EPB	Epothilone C/D epoxidase	1.14	0.460
1obn	ASV	Isopenicillin N synthase	1.21.3.1	0.458
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.458
4i1n	FOL	Dihydrofolate reductase	1.5.1.3	0.455
5hi6	MTX	Dihydrofolate reductase	/	0.455
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.454
4bgi	I4I	Enoyl-[acyl-carrier-protein] reductase [NADH]	1.3.1.9	0.454
1blz	ACV	Isopenicillin N synthase	1.21.3.1	0.453
1rx7	FOL	Dihydrofolate reductase	1.5.1.3	0.453
1uzw	CDH	Isopenicillin N synthase	1.21.3.1	0.453
4dvq	1CA	Cytochrome P450 11B2, mitochondrial	1.14.15.4	0.453
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.452
1rx5	DDF	Dihydrofolate reductase	1.5.1.3	0.451
1s3v	TQD	Dihydrofolate reductase	1.5.1.3	0.450
3s7a	684	Dihydrofolate reductase	1.5.1.3	0.450
3k1w	BFX	Renin	3.4.23.15	0.449
3zoi	M2W	Isopenicillin N synthase	1.21.3.1	0.449
4b12	C23	Glycylpeptide N-tetradecanoyltransferase	/	0.449
1mvt	DTM	Dihydrofolate reductase	1.5.1.3	0.448
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.446
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.446
3v94	WYQ	Phosphodiesterase	/	0.446
2g26	3LG	Renin	3.4.23.15	0.445
3g70	A5T	Renin	3.4.23.15	0.445
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.445
4bfz	ZVZ	Pantothenate kinase	2.7.1.33	0.445
1pqc	444	Oxysterols receptor LXR-beta	/	0.443
1oc1	ASV	Isopenicillin N synthase	1.21.3.1	0.442
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.442
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.441
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.441
1rx6	DDF	Dihydrofolate reductase	1.5.1.3	0.440
3g6z	A7T	Renin	3.4.23.15	0.440