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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ysjADPCalmodulin-like domain protein kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ysjADPCalmodulin-like domain protein kinase/1.000
1ig1ANPDeath-associated protein kinase 12.7.11.10.549
4qnyANPMitogen activated protein kinase, putative/0.513
2w4jADPDeath-associated protein kinase 12.7.11.10.511
1jklANPDeath-associated protein kinase 12.7.11.10.509
1qmzATPCyclin-dependent kinase 22.7.11.220.489
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.486
3bu5ATPInsulin receptor2.7.10.10.473
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.473
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.472
2cjmATPCyclin-dependent kinase 22.7.11.220.469
3gu7ADPDeath-associated protein kinase 12.7.11.10.468
1jkkANPDeath-associated protein kinase 12.7.11.10.466
3c4zADPRhodopsin kinase/0.466
2yaaATPDeath-associated protein kinase 2/0.464
5dosATPAurora kinase A2.7.11.10.463
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.461
3c4wATPRhodopsin kinase/0.459
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.459
5dnrATPAurora kinase A2.7.11.10.458
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.457
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.456
5eg3ACPFibroblast growth factor receptor 2/0.456
4deeADPAurora kinase A2.7.11.10.454
2j0lANPFocal adhesion kinase 12.7.10.20.452
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.450
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.449
3lltANPProtein serine/threonine kinase-1/0.449