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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4txzG2PCyclic GMP-AMP synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4txzG2PCyclic GMP-AMP synthase/1.000
4xj43ATCyclic GMP-AMP synthase/0.600
2oapANPType II secretion system protein (GspE-2)/0.468
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.455
2hldANPATP synthase subunit alpha, mitochondrial/0.455
2hldANPATP synthase subunit beta, mitochondrial3.6.3.140.455
1xddAAYIntegrin alpha-L/0.453
4egbNADdTDP-glucose 4,6-dehydratase/0.452
1u3dFADCryptochrome-1/0.450
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.450
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
1rdwLARActin, alpha skeletal muscle/0.445
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.445
2rlcCHDCholoylglycine hydrolase3.5.1.240.444
1cjuFOKAdenylate cyclase type 2/0.442
1cjuFOKAdenylate cyclase type 5/0.442
1gzuNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.442
4lcjNADC-terminal-binding protein 2/0.442
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.441
1tqf32PBeta-secretase 13.4.23.460.440
2hk9NAPShikimate dehydrogenase (NADP(+))/0.440
3a1nNADNDP-sugar epimerase/0.440
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.440