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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4rrfA3SThreonine--tRNA ligase6.1.1.3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4rrfA3SThreonine--tRNA ligase6.1.1.31.000
4rrgA3TThreonine--tRNA ligase6.1.1.30.643
3pd4A3GThreonine--tRNA ligase6.1.1.30.546
2hl2SSAThreonine--tRNA ligase6.1.1.30.545
2hl1A3SThreonine--tRNA ligase6.1.1.30.541
3pd5TSBThreonine--tRNA ligase6.1.1.30.527
3pd3A3TThreonine--tRNA ligase6.1.1.30.502
3pd2A3SThreonine--tRNA ligase6.1.1.30.499
4rriA3TProbable threonine--tRNA ligase 26.1.1.30.498
4rrrA3TThreonine--tRNA ligase6.1.1.30.498
4rrdA3TProbable threonine--tRNA ligase 26.1.1.30.494
4rrcA3TProbable threonine--tRNA ligase 26.1.1.30.492
4rrhA3SProbable threonine--tRNA ligase 26.1.1.30.492
4rr8A3SProbable threonine--tRNA ligase 26.1.1.30.489
4rrqA3SThreonine--tRNA ligase6.1.1.30.487
4rrbA3TProbable threonine--tRNA ligase 26.1.1.30.483
4rrmA3TProbable threonine--tRNA ligase 26.1.1.30.479
4rraA3TProbable threonine--tRNA ligase 26.1.1.30.478
4rr6A3SProbable threonine--tRNA ligase 26.1.1.30.471
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.466
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.464
1fmlRTLRetinol dehydratase/0.458
3q43D66M1 family aminopeptidase3.4.110.458
4rr9A3SProbable threonine--tRNA ligase 26.1.1.30.457
4rrlA3SProbable threonine--tRNA ligase 26.1.1.30.457
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.456
4xwtU5PRibonuclease J/0.453
3d5qT30Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.449
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.447
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1nhkCMPNucleoside diphosphate kinase2.7.4.60.446
4r81FMNPredicted NADH dehydrogenase/0.445
5cb3APRO-acetyl-ADP-ribose deacetylase/0.445
1xp6AIUEstrogen receptor/0.444
1f4fTP3Thymidylate synthase/0.443
1f4gTP4Thymidylate synthase/0.443
1r2jFADFkbI/0.442
3w0c6DSVitamin D3 receptor/0.442
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.441
2w4qCBWProstaglandin reductase 21.3.1.480.441
2imfTOM2-hydroxychromene-2-carboxylate isomerase5.99.1.40.440
2xweAMFGlucosylceramidase3.2.1.450.440