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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4rlsNAIL-lactate dehydrogenase A chain1.1.1.27

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4rlsNAIL-lactate dehydrogenase A chain1.1.1.271.000
3h3fNAIL-lactate dehydrogenase A chain1.1.1.270.594
2x0iNAIMalate dehydrogenase/0.572
4i8x6P3L-lactate dehydrogenase A chain1.1.1.270.560
1hygNAPL-2-hydroxycarboxylate dehydrogenase (NAD(P)(+))/0.558
4i1iNADMalate dehydrogenase/0.554
3gvhNADMalate dehydrogenase/0.552
2a92NAIL-lactate dehydrogenase/0.547
3wswNADL-lactate dehydrogenase/0.544
1ez4NADL-lactate dehydrogenase1.1.1.270.540
2ldbNADL-lactate dehydrogenase1.1.1.270.530
1b8uNADMalate dehydrogenase/0.520
4mdhNADMalate dehydrogenase, cytoplasmic1.1.1.370.513
3d4pNADL-lactate dehydrogenase 11.1.1.270.509
1bdmNAXMalate dehydrogenase/0.503
1o0sNAINAD-dependent malic enzyme, mitochondrial1.1.1.380.502
4jnkNAIL-lactate dehydrogenase A chain1.1.1.270.500
3pqfNADL-lactate dehydrogenase1.1.1.270.494
1f8fNADBenzyl alcohol dehydrogenase/0.493
4nd3NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.488
1ie3NADMalate dehydrogenase/0.486
1t2cNAIL-lactate dehydrogenase1.1.1.270.486
1wzeNADMalate dehydrogenase/0.485
3gfbNADL-threonine 3-dehydrogenase/0.485
2a94AP0L-lactate dehydrogenase1.1.1.270.484
1wziNDPMalate dehydrogenase/0.482
4i9n1E5L-lactate dehydrogenase A chain1.1.1.270.482
3h3jNADL-lactate dehydrogenase 11.1.1.270.480
1llqNADNAD-dependent malic enzyme, mitochondrial1.1.1.380.478
1mp0NADAlcohol dehydrogenase class-31.1.1.10.478
4ajn88VL-lactate dehydrogenase A chain1.1.1.270.478
1ma0NADAlcohol dehydrogenase class-31.1.1.10.477
4jjiNADAlcohol dehydrogenase class-3/0.477
1qr6NADNAD-dependent malic enzyme, mitochondrial1.1.1.380.473
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.472
1ur5NADMalate dehydrogenase/0.471
1bmdNADMalate dehydrogenase/0.470
2vwqNAPGlucose 1-dehydrogenase/0.466
4yaoFMNNADPH--cytochrome P450 reductase/0.466
3lqfNADGalactitol dehydrogenase/0.465
1uxjNADMalate dehydrogenase/0.464
4ajj88RL-lactate dehydrogenase A chain1.1.1.270.464
4uunNAIL-lactate dehydrogenase/0.464
1b8vNADMalate dehydrogenase/0.463
2fzwNADAlcohol dehydrogenase class-31.1.1.10.463
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.462
1h50FMNPentaerythritol tetranitrate reductase/0.461
1gv0NADMalate dehydrogenase/0.460
1uxkNADMalate dehydrogenase/0.460
2x0rNADMalate dehydrogenase/0.460
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
1xe55FEPlasmepsin-23.4.23.390.459
2ejvNADL-threonine 3-dehydrogenase/0.459
1tehNADAlcohol dehydrogenase class-31.1.1.10.458
4gl4NAIAlcohol dehydrogenase class-3/0.458
1guyNADMalate dehydrogenase/0.457
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.456
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.454
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
4hbgNDP3-oxoacyl-[acyl-carrier-protein] reductase1.1.1.1000.452
4q71FADBifunctional protein PutA/0.451
1a72PADAlcohol dehydrogenase E chain1.1.1.10.449
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.449
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.449
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.448
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.448
5jlaNADPutative short-chain dehydrogenase/reductase/0.448
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.447
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
1y7tNDPMalate dehydrogenase/0.446
2g8yNADHydroxycarboxylate dehydrogenase B/0.446
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.446
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.445
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.445
3p62FMNPentaerythritol tetranitrate reductase/0.444
3uylTYDProbable NDP-rhamnosyltransferase/0.444
4g3jVNTLanosterol 14-alpha-demethylase/0.444
1e3eNAIAlcohol dehydrogenase 41.1.1.10.443
1zemNADXylitol dehydrogenase/0.443
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
2dbzNAPGlyoxylate reductase1.1.1.260.441
1tqf32PBeta-secretase 13.4.23.460.440
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.440
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.440