sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4py6 | R78 | Bromodomain protein, putative |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4py6 | R78 | Bromodomain protein, putative | / | 1.000 | |
| 4uyg | 73B | Bromodomain-containing protein 2 | / | 0.531 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.528 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.518 | |
| 4alh | A9P | Bromodomain-containing protein 2 | / | 0.516 | |
| 4o70 | 1QK | Bromodomain-containing protein 4 | / | 0.515 | |
| 4bw3 | 9BM | Bromodomain-containing protein 4 | / | 0.514 | |
| 4flp | JQ1 | Bromodomain testis-specific protein | / | 0.510 | |
| 4c67 | L5S | Bromodomain-containing protein 4 | / | 0.505 | |
| 4a9m | P9M | Bromodomain-containing protein 2 | / | 0.502 | |
| 4akn | S5B | Bromodomain-containing protein 2 | / | 0.501 | |
| 2yek | EAM | Bromodomain-containing protein 2 | / | 0.500 | |
| 4a9i | P9I | Bromodomain-containing protein 2 | / | 0.491 | |
| 4o76 | 1M3 | Bromodomain-containing protein 4 | / | 0.489 | |
| 5bt5 | 2LO | Bromodomain-containing protein 2 | / | 0.489 | |
| 4a9e | 3PF | Bromodomain-containing protein 2 | / | 0.488 | |
| 4a9h | TVP | Bromodomain-containing protein 2 | / | 0.484 | |
| 4a9o | A9O | Bromodomain-containing protein 2 | / | 0.484 | |
| 4c66 | H4C | Bromodomain-containing protein 4 | / | 0.483 | |
| 4men | 25K | Bromodomain-containing protein 4 | / | 0.482 | |
| 4j0r | 1H2 | Bromodomain-containing protein 4 | / | 0.481 | |
| 4mr6 | 1K0 | Bromodomain-containing protein 2 | / | 0.481 | |
| 2ydw | WSH | Bromodomain-containing protein 2 | / | 0.480 | |
| 4hxs | 1A3 | Bromodomain-containing protein 4 | / | 0.480 | |
| 4lyw | 21Q | Bromodomain-containing protein 4 | / | 0.473 | |
| 4j1p | 1K0 | Bromodomain-containing protein 2 | / | 0.472 | |
| 4mr5 | 1K0 | Bromodomain-containing protein 2 | / | 0.472 | |
| 2yel | WSH | Bromodomain-containing protein 4 | / | 0.470 | |
| 4hxr | 1A4 | Bromodomain-containing protein 4 | / | 0.470 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.469 | |
| 4e96 | 0NS | Bromodomain-containing protein 4 | / | 0.468 | |
| 4lrg | 1XB | Bromodomain-containing protein 4 | / | 0.466 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.466 | |
| 1qnf | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.465 | |
| 2yem | WSH | Bromodomain-containing protein 4 | / | 0.464 | |
| 4j0s | 1H3 | Bromodomain-containing protein 4 | / | 0.464 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.462 | |
| 4bjx | 73B | Bromodomain-containing protein 4 | / | 0.462 | |
| 4mr4 | 1K0 | Bromodomain-containing protein 4 | / | 0.460 | |
| 4nqm | Y1Z | Bromodomain-containing protein 4 | / | 0.459 | |
| 4ogi | R78 | Bromodomain-containing protein 4 | / | 0.459 | |
| 4a9n | A9N | Bromodomain-containing protein 2 | / | 0.458 | |
| 4mep | 24Y | Bromodomain-containing protein 4 | / | 0.458 | |
| 4bw2 | UTH | Bromodomain-containing protein 4 | / | 0.457 | |
| 4o74 | R78 | Bromodomain-containing protein 4 | / | 0.456 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 3aqa | BYH | Bromodomain-containing protein 2 | / | 0.454 | |
| 4a9l | P9L | Bromodomain-containing protein 4 | / | 0.452 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 1owl | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.450 | |
| 1tez | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.450 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.450 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 1osv | CHC | Bile acid receptor | / | 0.449 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.448 | |
| 3iqf | E4M | F420-dependent methylenetetrahydromethanopterin dehydrogenase | 1.5.98.1 | 0.448 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2jfg | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
| 4bw4 | 9B6 | Bromodomain-containing protein 4 | / | 0.445 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.444 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 1dnp | FAD | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.443 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.443 | |
| 4ax8 | ADP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.443 | |
| 2nr4 | FMN | Conserved protein | / | 0.442 | |
| 4meq | 25O | Bromodomain-containing protein 4 | / | 0.442 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.441 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.441 | |
| 3t14 | FAD | Sulfide-quinone reductase | / | 0.441 | |
| 4f3i | 0S6 | Bromodomain-containing protein 4 | / | 0.441 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4o78 | SAV | Bromodomain-containing protein 4 | / | 0.441 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.440 |