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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4pxzCLRP2Y purinoceptor 12

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4pxzCLRP2Y purinoceptor 12/1.000
4py06ATP2Y purinoceptor 12/0.533
5dp2NAPCurF/0.500
2nmtMIMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.472
4pl0ANPMicrocin-J25 export ATP-binding/permease protein McjD/0.472
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.468
5dozNDPJamJ/0.466
1vbiNADMalate/L-lactate dehydrogenase family protein/0.464
2gfxPMN3-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.463
2xlpNAPPutative flavin-containing monooxygenase/0.463
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.462
3gwfFADCyclohexanone monooxygenase/0.461
3ox1695Ribosyldihydronicotinamide dehydrogenase [quinone]/0.460
3cr0809Wee1-like protein kinase2.7.10.20.459
3bw4FMNPutative 2-nitropropane dioxygenase/0.458
3v0p4GWHisto-blood group ABO system transferase/0.458
3w5uFADFerredoxin/0.458
8catNDPCatalase1.11.1.60.458
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.457
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.456
2xlrFADPutative flavin-containing monooxygenase/0.455
2yac937Serine/threonine-protein kinase PLK12.7.11.210.455
3nhjA2ZRibosyldihydronicotinamide dehydrogenase [quinone]/0.454
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.454
2gevCOKPantothenate kinase2.7.1.330.453
1gaqFADFerredoxin/0.451
2am22LGUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.451
4gv8DUPDUTPase/0.451
3b9oFMNAlkane monoxygenase/0.448
3ox34X4Ribosyldihydronicotinamide dehydrogenase [quinone]/0.448
4cf6CBDNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1wngSAHDiphthine synthase/0.447
2e7rSAHDiphthine synthase/0.447
2e8hSAHDiphthine synthase/0.447
3kek3EKCollagenase 33.4.240.447
4tm1FDAKtzI/0.447
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.446
2emrSAHDiphthine synthase/0.446
1wkhPPE[LysW]-aminoadipate semialdehyde transaminase/0.445
3cz7ACOHistone acetyltransferase RTT1092.3.1.480.445
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.445
4qak2AMRNA 2',3'-cyclic phosphodiesterase/0.445
2e15SAHDiphthine synthase/0.444
2e8qSAHDiphthine synthase/0.444
2dsgSAHDiphthine synthase/0.443
2e07SAHDiphthine synthase/0.443
2v6gNAP3-oxo-Delta(4,5)-steroid 5-beta-reductase/0.443
3r95ACOMccE protein/0.443
4ohwATPProtein clpf-1/0.443
1cnfFADNitrate reductase [NADH]1.7.1.10.442
1x8b824Wee1-like protein kinase2.7.10.20.442
2xvfFADPutative flavin-containing monooxygenase/0.442
3e4aQIXInsulin-degrading enzyme3.4.24.560.442
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.442
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1pagFMPAntiviral protein I3.2.2.220.441
2pb6SAHDiphthine synthase/0.441
3l77NJPShort-chain alcohol dehydrogenase/0.441
2dekSAHDiphthine synthase/0.440
2egbSAHDiphthine synthase/0.440
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.440
3adaNADSubunit alpha of sarocosine oxidase/0.440
5a2yUTPMitochondrial poly(A) polymerase/0.440