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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4oa5SAHO-methyltransferase family protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4oa5SAHO-methyltransferase family protein/1.000
1susSAHCaffeoyl-CoA O-methyltransferase2.1.1.1040.543
2hnkSAHSAM-dependent O-methyltransferase/0.524
3cbgSAHO-methyltransferase/0.523
3lgaSAHtRNA (adenine(57)-N(1)/adenine(58)-N(1))-methyltransferase TrmI2.1.1.2190.510
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.509
3duwSAHO-methyltransferase, putative/0.508
3swrSFGDNA (cytosine-5)-methyltransferase 12.1.1.370.503
3a7dFBNCatechol O-methyltransferase2.1.1.60.501
3tr6SAHO-methyltransferase/0.493
4ymgSAMPutative SAM-dependent O-methyltranferase/0.492
3egvSAHRibosomal protein L11 methyltransferase2.1.10.481
4u7tSAHDNA (cytosine-5)-methyltransferase 3A2.1.1.370.481
4h0nSAHDnmt2/0.476
3c3ySAHO-methyltransferase/0.475
3v97SAHRibosomal RNA large subunit methyltransferase K/L2.1.1.1730.475
3grySAMProbable ribosomal RNA small subunit methyltransferase A/0.473
4c04SFGProtein arginine N-methyltransferase 6/0.473
1jr4CL4Catechol O-methyltransferase2.1.1.60.469
2pwySAHtRNA (adenine(58)-N(1))-methyltransferase TrmI2.1.1.2200.469
3hvk719Catechol O-methyltransferase2.1.1.60.469
4qppSAHProtein arginine N-methyltransferase 6/0.469
1zq9SAMProbable dimethyladenosine transferase/0.465
3nw9637Catechol O-methyltransferase2.1.1.60.465
3ssmSAHMycinamicin VI 2''-O-methyltransferase/0.465
3v8vSAMRibosomal RNA large subunit methyltransferase K/L2.1.1.1730.465
4fzvSAM5-methylcytosine rRNA methyltransferase NSUN42.1.10.464
3ssoSAHMycinamicin VI 2''-O-methyltransferase/0.463
5bp9SAHPutative methyltransferase protein/0.463
3orhSAHGuanidinoacetate N-methyltransferase2.1.1.20.462
4c05SAHProtein arginine N-methyltransferase 6/0.461
2bm9SAMCephalosporin hydroxylase CmcI/0.460
4y93746Tyrosine-protein kinase/0.460
2nxeSAMRibosomal protein L11 methyltransferase2.1.10.459
3cjtSAHRibosomal protein L11 methyltransferase2.1.10.459
3ldfSAHUncharacterized protein/0.458
4pyoSAHCatechol O-methyltransferase2.1.1.60.458
3qv2SAH5-cytosine DNA methyltransferase/0.456
3gfbNADL-threonine 3-dehydrogenase/0.454
3ozsOZSCatechol O-methyltransferase2.1.1.60.454
2plwSAMRibosomal RNA methyltransferase, putative/0.452
1o94ADPTrimethylamine dehydrogenase1.5.8.20.451
3a4vNADNDP-sugar epimerase/0.451
3nwb659Catechol O-methyltransferase2.1.1.60.449
4dpwAGSMevalonate diphosphate decarboxylase/0.449
4n3cUD1UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.448
5e72SAMN2, N2-dimethylguanosine tRNA methyltransferase/0.446
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.445
3q87SAMN6 ADENINE SPECIFIC DNA METHYLASE (METHYLTRANSFERASE SUPERFAMILY)/0.444
4rtlSFGDNA adenine methylase2.1.1.720.444
4wxxSAHDNA (cytosine-5)-methyltransferase 12.1.1.370.444
3bv3P39Mitogen-activated protein kinase 14/0.443
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.443
3nu9478Gag-Pol polyprotein3.4.23.160.443
3pt9SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.443
3ua3SAHProtein arginine N-methyltransferase 5/0.443
1nzdUPGDNA beta-glucosyltransferase/0.442
2x3nFADProbable FAD-dependent monooxygenase/0.442
3jvwDMPGag-Pol polyprotein3.4.23.160.442
3lovFADProtoporphyrinogen oxidase/0.442
5ifiPRXAcetyl-coenzyme A synthetase/0.442
1adcPADAlcohol dehydrogenase E chain1.1.1.10.441
1i9gSAMtRNA (adenine(58)-N(1))-methyltransferase TrmI/0.441
1oriSAHProtein arginine N-methyltransferase 1/0.441
2yr4FADPhenylalanine 2-monooxygenase precursor1.13.12.90.441
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.441
3b895GP16S rRNA methylase/0.440
4xgxADPFAD:protein FMN transferase/0.440