scPDB - Distribution of Binding site Similarity values of 4m2x entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4m2x	TMQ	Dihydrofolate reductase	1.5.1.3	1.000
1dg5	TOP	Dihydrofolate reductase	1.5.1.3	0.558
1hfq	MOT	Dihydrofolate reductase	1.5.1.3	0.550
1df7	MTX	Dihydrofolate reductase	1.5.1.3	0.541
3qls	55V	Dihydrofolate reductase	1.5.1.3	0.533
1rx3	MTX	Dihydrofolate reductase	1.5.1.3	0.532
3qlz	QLZ	Uncharacterized protein	/	0.531
1cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.528
1vj3	TAB	Dihydrofolate reductase	1.5.1.3	0.525
1dg7	WRB	Dihydrofolate reductase	1.5.1.3	0.522
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.522
4ixe	IXE	Dihydrofolate reductase	1.5.1.3	0.522
1hfp	MOT	Dihydrofolate reductase	1.5.1.3	0.521
4h97	53S	Dihydrofolate reductase	1.5.1.3	0.518
3iro	2CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.514
3inv	C50	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.513
3kjs	DQ1	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.511
3sa1	6DR	Dihydrofolate reductase	/	0.511
4h96	14Q	Dihydrofolate reductase	1.5.1.3	0.510
2w3v	TOP	Dihydrofolate reductase	/	0.508
2fzi	DH3	Dihydrofolate reductase	1.5.1.3	0.507
1klk	PMD	Dihydrofolate reductase	1.5.1.3	0.505
1m7a	MQU	Dihydrofolate reductase	1.5.1.3	0.501
3qfx	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.501
1dra	MTX	Dihydrofolate reductase	1.5.1.3	0.500
3qlx	QLR	Uncharacterized protein	/	0.500
3qlw	N22	Dihydrofolate reductase	1.5.1.3	0.499
4cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.499
3dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.498
3tq9	MTX	Dihydrofolate reductase	/	0.496
2cd2	FOL	Dihydrofolate reductase	1.5.1.3	0.495
3cse	N22	Uncharacterized protein	/	0.494
3qlr	QLR	Dihydrofolate reductase	1.5.1.3	0.494
1jol	FFO	Dihydrofolate reductase	1.5.1.3	0.493
2w9s	TOP	Dihydrofolate reductase type 1 from Tn4003	1.5.1.3	0.493
3eej	53R	Uncharacterized protein	/	0.493
4fgh	0U6	Dihydrofolate reductase	1.5.1.3	0.493
3drc	MTX	Dihydrofolate reductase	1.5.1.3	0.492
4h98	14Q	Uncharacterized protein	/	0.492
3eek	53S	Uncharacterized protein	/	0.490
3eel	53T	Uncharacterized protein	/	0.490
3jsu	KA5	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.490
3qly	55V	Uncharacterized protein	/	0.489
3td8	D2R	Dihydrofolate reductase	1.5.1.3	0.488
4fgg	0U5	Dihydrofolate reductase	1.5.1.3	0.488
4x5g	FOL	Dihydrofolate reductase	1.5.1.3	0.487
1aoe	GW3	Dihydrofolate reductase	1.5.1.3	0.484
3jw5	TOP	Dihydrofolate reductase	/	0.484
4xe6	06U	Dihydrofolate reductase	1.5.1.3	0.484
1dds	MTX	Dihydrofolate reductase	1.5.1.3	0.483
2zza	FOL	Dihydrofolate reductase	/	0.483
3eem	53V	Uncharacterized protein	/	0.482
3ia4	MTX	Dihydrofolate reductase	/	0.482
3och	2MX	Dihydrofolate reductase	1.5.1.3	0.482
3fyw	XCF	Dihydrofolate reductase	1.5.1.3	0.480
3tqb	FOL	Dihydrofolate reductase	/	0.479
3dga	RJ1	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.478
4ixg	IXG	Dihydrofolate reductase	1.5.1.3	0.478
3jwc	EKB	Dihydrofolate reductase	/	0.476
3srq	Q19	Dihydrofolate reductase	1.5.1.3	0.476
1jom	FFO	Dihydrofolate reductase	1.5.1.3	0.475
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.475
1re7	FOL	Dihydrofolate reductase	1.5.1.3	0.472
4h95	06U	Dihydrofolate reductase	1.5.1.3	0.472
2fzh	DH1	Dihydrofolate reductase	1.5.1.3	0.471
3ix9	MTX	Dihydrofolate reductase	1.5.1.3	0.471
4x5j	FOL	Dihydrofolate reductase	1.5.1.3	0.470
3fl8	RAR	Dihydrofolate reductase	/	0.469
3sa2	7DR	Dihydrofolate reductase	/	0.469
3srw	Q27	Dihydrofolate reductase	1.5.1.3	0.469
4dfr	MTX	Dihydrofolate reductase	1.5.1.3	0.469
1rb3	MTX	Dihydrofolate reductase	1.5.1.3	0.468
1rf7	DHF	Dihydrofolate reductase	1.5.1.3	0.468
1e26	GPB	Dihydrofolate reductase	1.5.1.3	0.467
4ixf	IXF	Dihydrofolate reductase	1.5.1.3	0.466
3um6	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.465
4ele	31I	Dihydrofolate reductase	/	0.465
4g8z	TOP	Dihydrofolate reductase	1.5.1.3	0.465
3m08	RAR	Dihydrofolate reductase	1.5.1.3	0.464
3ntz	3TZ	Dihydrofolate reductase	1.5.1.3	0.464
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.463
3d80	Q22	Dihydrofolate reductase	1.5.1.3	0.463
5ccc	DDF	Dihydrofolate reductase	1.5.1.3	0.462
3frd	DHF	Dihydrofolate reductase	1.5.1.3	0.461
3fre	TOP	Dihydrofolate reductase	1.5.1.3	0.460
4x5f	FOL	Dihydrofolate reductase	1.5.1.3	0.460
1daj	MOT	Dihydrofolate reductase	1.5.1.3	0.459
3fy9	XCF	Dihydrofolate reductase	1.5.1.3	0.459
3l3r	OAG	Dihydrofolate reductase	1.5.1.3	0.459
1j3i	WRA	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.457
4fjy	FJY	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.457
1ohk	COP	Dihydrofolate reductase	1.5.1.3	0.456
1rc4	DDF	Dihydrofolate reductase	1.5.1.3	0.456
4m6l	21V	Dihydrofolate reductase	1.5.1.3	0.456
1kij	NOV	DNA gyrase subunit B	/	0.455
2hw2	RFP	Rifampin ADP-ribosyl transferase	/	0.455
4dpd	DHF	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.455
2bla	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.454
3irn	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.453
3sai	9DR	Dihydrofolate reductase	/	0.453
4nx6	FOL	Dihydrofolate reductase	1.5.1.3	0.453
2fzj	DH3	Dihydrofolate reductase	1.5.1.3	0.452
3fra	I2H	Dihydrofolate reductase	1.5.1.3	0.452
3fyv	XCF	Dihydrofolate reductase	1.5.1.3	0.452
3sh2	5DR	Dihydrofolate reductase	1.5.1.3	0.452
5hi6	MTX	Dihydrofolate reductase	/	0.452
1ly3	COG	Dihydrofolate reductase	1.5.1.3	0.451
3r33	6ME	Dihydrofolate reductase	1.5.1.3	0.451
4elb	34S	Dihydrofolate reductase	/	0.451
4p66	MTX	Dihydrofolate reductase	/	0.451
2drc	MTX	Dihydrofolate reductase	1.5.1.3	0.450
2w3w	VG9	Dihydrofolate reductase	/	0.450
4nx7	FOL	Dihydrofolate reductase	1.5.1.3	0.450
1drb	MTX	Dihydrofolate reductase	1.5.1.3	0.449
1rg7	MTX	Dihydrofolate reductase	1.5.1.3	0.449
3cd2	MTX	Dihydrofolate reductase	1.5.1.3	0.449
3nrr	D16	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.449
4ej1	FOL	Dihydrofolate reductase	1.5.1.3	0.449
1ddr	MTX	Dihydrofolate reductase	1.5.1.3	0.447
1rd7	FOL	Dihydrofolate reductase	1.5.1.3	0.447
2blc	CP7	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.447
4jlj	1NM	Deoxycytidine kinase	2.7.1.74	0.447
1dyj	DDF	Dihydrofolate reductase	1.5.1.3	0.446
3frf	XCF	Dihydrofolate reductase	1.5.1.3	0.446
3sru	Q26	Dihydrofolate reductase	1.5.1.3	0.446
4iv2	1GR	Estrogen receptor	/	0.446
1qzf	FOL	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.445
3clb	TMQ	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.444
1diu	BDM	Dihydrofolate reductase	1.5.1.3	0.443
1mkd	ZAR	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	3.1.4.53	0.443
1tdr	MTX	Dihydrofolate reductase	1.5.1.3	0.443
3dat	MTX	Dihydrofolate reductase	/	0.443
7dfr	FOL	Dihydrofolate reductase	1.5.1.3	0.443
1s3y	TQT	Dihydrofolate reductase	1.5.1.3	0.441
3srr	Q20	Dihydrofolate reductase	1.5.1.3	0.441
4kd7	9DR	Dihydrofolate reductase	1.5.1.3	0.441
4qi9	MTX	Dihydrofolate reductase	/	0.441
1dhj	MTX	Dihydrofolate reductase	1.5.1.3	0.440
2chw	039	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	2.7.1.153	0.440
2q66	ATP	Poly(A) polymerase	2.7.7.19	0.440
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.440