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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4kzuA73Tankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4kzuA73Tankyrase-22.4.2.301.000
4l31F08Tankyrase-22.4.2.300.800
4l0i1UWTankyrase-22.4.2.300.777
3kr8XAVTankyrase-22.4.2.300.732
4l0t1V0Tankyrase-22.4.2.300.622
4bu908CTankyrase-22.4.2.300.619
4hkkAGITankyrase-22.4.2.300.616
4hknLU2Tankyrase-22.4.2.300.616
4l10A63Tankyrase-22.4.2.300.612
4bufF36Tankyrase-22.4.2.300.611
4l341VGTankyrase-22.4.2.300.607
4hlg20BTankyrase-22.4.2.300.601
4bud29FTankyrase-22.4.2.300.596
4bueJQFTankyrase-22.4.2.300.594
4buxF35Tankyrase-22.4.2.300.593
4hlh20DTankyrase-22.4.2.300.593
4hlk431Tankyrase-22.4.2.300.593
4buuF38Tankyrase-22.4.2.300.592
4l0s1UZTankyrase-22.4.2.300.591
4l33F70Tankyrase-22.4.2.300.590
4buiW2ETankyrase-22.4.2.300.588
4hlm16STankyrase-22.4.2.300.585
4hlf15ZTankyrase-22.4.2.300.582
4iueAJ4Tankyrase-22.4.2.300.579
4l2k1V8Tankyrase-22.4.2.300.579
4l2g1V4Tankyrase-22.4.2.300.574
4hl515WTankyrase-22.4.2.300.573
4l321VFTankyrase-22.4.2.300.571
4j21AJ6Tankyrase-22.4.2.300.566
5aku29FTankyrase-22.4.2.300.560
4kzl20DTankyrase-22.4.2.300.559
4but31FTankyrase-22.4.2.300.554
4bus32FTankyrase-22.4.2.300.551
4l0v1V1Tankyrase-22.4.2.300.551
4l2f1V3Tankyrase-22.4.2.300.548
4j22AJ7Tankyrase-22.4.2.300.541
4buwF33Tankyrase-22.4.2.300.531
4avwG18Tankyrase-22.4.2.300.529
4hkiFLNTankyrase-22.4.2.300.519
4hmhF94Tankyrase-22.4.2.300.516
4bs4A64Tankyrase-22.4.2.300.512
4bjbP34Tankyrase-22.4.2.300.487
3p0pNNFTankyrase-22.4.2.300.486
4pnrG18Tankyrase-22.4.2.300.486
4bj9UHBTankyrase-22.4.2.300.471
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.457
4tkg09LTankyrase-22.4.2.300.456
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.452
4l091URTankyrase-22.4.2.300.451
4pnmNU1Tankyrase-22.4.2.300.450
4buv16ITankyrase-22.4.2.300.447
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.447