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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4k41ATPActin, alpha skeletal muscle

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4k41ATPActin, alpha skeletal muscle/1.000
4pl8ATPActin, alpha skeletal muscle/0.677
1t44ATPActin, alpha skeletal muscle/0.641
4pkgATPActin, alpha skeletal muscle/0.634
1qz5ATPActin, alpha skeletal muscle/0.630
1s22ATPActin, alpha skeletal muscle/0.624
3eksATPActin-5C/0.620
1lotATPActin, alpha skeletal muscle/0.618
3el2ATPActin-5C/0.615
1c0fATPMajor actin/0.607
2q36ATPActin, alpha skeletal muscle/0.601
3tu5ATPActin, alpha skeletal muscle/0.601
4k42ADPActin, alpha skeletal muscle/0.594
3mn7ATPActin-5C/0.591
4k43ADPActin, alpha skeletal muscle/0.589
1nm1ATPMajor actin/0.587
1rgiATPActin, alpha skeletal muscle/0.586
3m6gATPActin, alpha skeletal muscle/0.586
3mn6ATPActin-5C/0.585
4ci6ATPActin/0.584
1yxqATPActin, alpha skeletal muscle/0.582
1h1vATPActin, alpha skeletal muscle/0.580
4cbxATPActin-2/0.580
3mn9ATPActin-5C/0.578
3ffkATPActin, alpha skeletal muscle/0.577
5ce3ATPActin/0.577
4jhdANPActin-5C/0.572
1eqyATPActin, alpha skeletal muscle/0.570
1nmdATPMajor actin/0.568
2p9kATPActin-related protein 2/0.568
3a5mATPMajor actin/0.566
1ijjATPActin, alpha skeletal muscle/0.561
4pkhADPActin, alpha skeletal muscle/0.561
2q97ATPActin, alpha skeletal muscle/0.556
3dawATPActin, alpha skeletal muscle/0.553
3u9dATPActin, alpha skeletal muscle/0.551
4m63ATPActin-5C/0.551
3u4lATPActin, cytoplasmic 1/0.546
2oanATPActin, cytoplasmic 1/0.537
2v51ATPActin, alpha skeletal muscle/0.536
1kxpATPActin, alpha skeletal muscle/0.531
1dejATPMajor actin/0.525
4rwtANPActin-5C/0.525
1mduATPActin, alpha skeletal muscle/0.521
4pkiATPActin, alpha skeletal muscle/0.518
3a5oATPMajor actin/0.503
3m1fATPActin, alpha skeletal muscle/0.495
1wuaATPActin, alpha skeletal muscle/0.490
3w3dATPActin, gamma-enteric smooth muscle/0.486
3chwATPMajor actin/0.479
3ekuATPActin-5C/0.477
1nlvATPMajor actin/0.472
5eoxADPType 4 fimbrial biogenesis protein PilM/0.471
2a41ATPActin, alpha skeletal muscle/0.470
5eoyADPType 4 fimbrial biogenesis protein PilM/0.465
3uleATPActin-related protein 2/0.453