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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4j57FADThioredoxin reductase 21.8.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4j57FADThioredoxin reductase 21.8.1.91.000
4j56FADThioredoxin reductase 21.8.1.90.592
1tytFADTrypanothione reductase1.8.1.120.577
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.569
2hqmFADGlutathione reductase1.8.1.70.555
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.552
4la1FADThioredoxin glutathione reductase/0.547
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.546
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.544
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.539
4dnaFADProbable glutathione reductase/0.539
2jk6FADTrypanothione reductase/0.538
1fecFADTrypanothione reductase1.8.1.120.537
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.529
1febFADTrypanothione reductase1.8.1.120.524
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.523
4nevFADTrypanothione reductase/0.517
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.514
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.513
1grhFADGlutathione reductase, mitochondrial1.8.1.70.510
3grsFADGlutathione reductase, mitochondrial1.8.1.70.509
1bzlFADTrypanothione reductase1.8.1.120.508
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.500
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.499
2wbaFADTrypanothione reductase1.8.1.120.496
1typFADTrypanothione reductase1.8.1.120.495
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.90.493
1greFADGlutathione reductase, mitochondrial1.8.1.70.489
1grgFADGlutathione reductase, mitochondrial1.8.1.70.488
1zx9FADMercuric reductase1.16.1.10.488
1gxfFADTrypanothione reductase1.8.1.120.481
2x8hFADThioredoxin glutathione reductase/0.481
4b1bFADThioredoxin reductase1.8.1.90.478
2v6oFADThioredoxin glutathione reductase/0.476
2eq9FADDihydrolipoyl dehydrogenase/0.475
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.468
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.468
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.466
3qfaFADThioredoxin reductase 1, cytoplasmic1.8.1.90.466
2eq6FADDihydrolipoyl dehydrogenase/0.465
2wp5FADTrypanothione reductase/0.465
2yquFADDihydrolipoyl dehydrogenase/0.460
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.455
2x8gFADThioredoxin glutathione reductase/0.453
4eqwFADCoenzyme A disulfide reductase/0.449