sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4imp | NDP | Polyketide synthase extender modules 3-4 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4imp | NDP | Polyketide synthase extender modules 3-4 | / | 1.000 | |
| 2yut | NAP | Putative short-chain oxidoreductase | / | 0.524 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.502 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.494 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.491 | |
| 4qec | NAP | ElxO | / | 0.489 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.482 | |
| 4pvd | NDP | NADPH-dependent methylglyoxal reductase GRE2 | / | 0.482 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.479 | |
| 1cyd | NDP | Carbonyl reductase [NADPH] 2 | 1.1.1.184 | 0.476 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.476 | |
| 1sny | NAP | LD36273p | / | 0.475 | |
| 4dc1 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.475 | |
| 4j7x | NAP | Sepiapterin reductase | 1.1.1.153 | 0.475 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.474 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.471 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.469 | |
| 4j7u | NAP | Sepiapterin reductase | 1.1.1.153 | 0.469 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.468 | |
| 3sju | NDP | Keto reductase | / | 0.466 | |
| 4jbi | NDP | Alcohol dehydrogenase (Zinc) | / | 0.466 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.465 | |
| 4bmv | NAP | Short-chain dehydrogenase | / | 0.465 | |
| 3bhi | NAP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.464 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.461 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.461 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.461 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.459 | |
| 5emh | NAP | Iridoid synthase | 1.3.1.99 | 0.459 | |
| 2jah | NDP | Clavaldehyde dehydrogenase | / | 0.458 | |
| 4i5e | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.457 | |
| 4fc7 | NAP | Peroxisomal 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.456 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.455 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.454 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.453 | |
| 5dcy | NAP | Iridoid synthase | 1.3.1.99 | 0.453 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.450 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.447 | |
| 1sby | NAD | Alcohol dehydrogenase | 1.1.1.1 | 0.447 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.447 | |
| 4b8z | NAP | GDP-L-fucose synthase | 1.1.1.271 | 0.447 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.445 | |
| 4qed | NAP | ElxO | / | 0.444 | |
| 4rf2 | NAP | NADPH dependent R-specific alcohol dehydrogenase | / | 0.444 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.443 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.443 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.442 | |
| 1oaa | NAP | Sepiapterin reductase | 1.1.1.153 | 0.442 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.442 | |
| 1wnt | NAP | L-xylulose reductase | 1.1.1.10 | 0.440 | |
| 1ybm | NAP | Uncharacterized protein At5g02240 | / | 0.440 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.440 |