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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4hlm16STankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4hlm16STankyrase-22.4.2.301.000
4hkkAGITankyrase-22.4.2.300.683
4l31F08Tankyrase-22.4.2.300.662
4l0t1V0Tankyrase-22.4.2.300.642
4l0s1UZTankyrase-22.4.2.300.633
4hl515WTankyrase-22.4.2.300.629
4bufF36Tankyrase-22.4.2.300.626
4kzuA73Tankyrase-22.4.2.300.626
4bud29FTankyrase-22.4.2.300.624
4bueJQFTankyrase-22.4.2.300.624
4buxF35Tankyrase-22.4.2.300.621
4l33F70Tankyrase-22.4.2.300.621
4l0v1V1Tankyrase-22.4.2.300.620
4kzl20DTankyrase-22.4.2.300.618
4l0i1UWTankyrase-22.4.2.300.617
4hlf15ZTankyrase-22.4.2.300.616
4l2f1V3Tankyrase-22.4.2.300.614
4bu908CTankyrase-22.4.2.300.610
4bus32FTankyrase-22.4.2.300.609
4l2k1V8Tankyrase-22.4.2.300.607
5aku29FTankyrase-22.4.2.300.605
4j22AJ7Tankyrase-22.4.2.300.603
4iueAJ4Tankyrase-22.4.2.300.602
4l321VFTankyrase-22.4.2.300.602
4buwF33Tankyrase-22.4.2.300.601
4j21AJ6Tankyrase-22.4.2.300.601
4l2g1V4Tankyrase-22.4.2.300.600
4l341VGTankyrase-22.4.2.300.600
4buuF38Tankyrase-22.4.2.300.598
4l10A63Tankyrase-22.4.2.300.596
4bs4A64Tankyrase-22.4.2.300.595
4hmhF94Tankyrase-22.4.2.300.593
4hlk431Tankyrase-22.4.2.300.590
4avwG18Tankyrase-22.4.2.300.589
3kr8XAVTankyrase-22.4.2.300.587
4hlh20DTankyrase-22.4.2.300.584
4but31FTankyrase-22.4.2.300.576
4krs1SXTankyrase-12.4.2.300.569
4buiW2ETankyrase-22.4.2.300.568
4bj9UHBTankyrase-22.4.2.300.562
4hkiFLNTankyrase-22.4.2.300.559
4l091URTankyrase-22.4.2.300.559
4tkg09LTankyrase-22.4.2.300.558
4hknLU2Tankyrase-22.4.2.300.557
4pnrG18Tankyrase-22.4.2.300.554
4hlg20BTankyrase-22.4.2.300.548
4j3mAJ8Tankyrase-22.4.2.300.544
3p0pNNFTankyrase-22.4.2.300.540
4bjbP34Tankyrase-22.4.2.300.532
4msk2C8Tankyrase-12.4.2.300.530
4buv16ITankyrase-22.4.2.300.515
4avuLDRTankyrase-22.4.2.300.506
4j3lAJ5Tankyrase-22.4.2.300.501
4i9i1DYTankyrase-12.4.2.300.497
4hyf1AKTankyrase-22.4.2.300.493
4pnmNU1Tankyrase-22.4.2.300.493
4tjy3GNTankyrase-22.4.2.300.482
4bjcRPBTankyrase-22.4.2.300.481
4mt92D6Tankyrase-12.4.2.300.475
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.458
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.457
1xk9P34Exotoxin A2.4.2.360.456
1lnmDTXBilin-binding protein/0.452
4li71XPTankyrase-12.4.2.300.447
3b78NADExotoxin A2.4.2.360.443
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.443
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3tqcADPPantothenate kinase/0.441
4pkl1GHUncharacterized protein/0.441
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.440
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.440
4dvi2IWTankyrase-12.4.2.300.440
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.440
4n4v2GYTankyrase-12.4.2.300.440