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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.10

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.101.000
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.100.810
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.712
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.653
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.640
3iczPB6Farnesyl pyrophosphate synthase/0.569
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.100.563
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.562
3egt722Farnesyl pyrophosphate synthase/0.558
3rywK9HFarnesyl pyrophosphate synthase, putative/0.524
3dyh721Farnesyl pyrophosphate synthase/0.518
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.100.517
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.504
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.472
1q6t600Tyrosine-protein phosphatase non-receptor type 13.1.3.480.468
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.458
2xlrFADPutative flavin-containing monooxygenase/0.457
2oxtSAMGenome polyprotein/0.454
5irnADPNucleotide binding oligomerization domain containing 2/0.454
5iqiGNPBifunctional AAC/APH2.3.10.453
4d0lGSPRas-related protein Rab-11A/0.452
1ppjANYCytochrome b/0.450
3q8uADPNucleoside diphosphate kinase/0.450
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.449
3qtxX43Cyclin-dependent kinase 22.7.11.220.449
4blsAPCNTPase P4/0.448
1dr2TAPDihydrofolate reductase1.5.1.30.447
2nq8ZIDEnoyl-ACP reductase/0.447
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.447
3gqvNAPEnoyl reductase LovC10.447
4wdfA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.447
1vrwNAIEnoyl-ACP reductase/0.446
2ylzFADPhenylacetone monooxygenase1.14.13.920.446
3dagFEG5,10-methenyltetrahydromethanopterin hydrogenase1.12.98.20.446
3p8z36AGenome polyprotein2.1.1.560.445
1n83CLRNuclear receptor ROR-alpha/0.444
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.444
1q6s214Tyrosine-protein phosphatase non-receptor type 13.1.3.480.443
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3nga3NGCasein kinase II subunit alpha2.7.11.10.443
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.441
3t88S0N1,4-dihydroxy-2-naphthoyl-CoA synthase/0.441
3toxNAPPutative oxidoreductase/0.441
3w8dNAD3-hydroxybutyrate dehydrogenase/0.441
4i421HA1,4-dihydroxy-2-naphthoyl-CoA synthase/0.441
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.441
1piwNAPNADP-dependent alcohol dehydrogenase 61.1.1.20.440
3p4tFAOPutative acyl-CoA dehydrogenase/0.440
3s1h56ZCyclin-dependent kinase 22.7.11.220.440
4hx519VCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440