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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4h4wFADBiphenyl dioxygenase ferredoxin reductase subunit

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4h4wFADBiphenyl dioxygenase ferredoxin reductase subunit/1.000
2gqwFADFerredoxin reductase/0.703
4h4vFADBiphenyl dioxygenase ferredoxin reductase subunit/0.689
4h4sFADBiphenyl dioxygenase ferredoxin reductase subunit/0.665
4h4rFADBiphenyl dioxygenase ferredoxin reductase subunit/0.619
4h4tFADBiphenyl dioxygenase ferredoxin reductase subunit/0.617
2gr3FADFerredoxin reductase/0.613
1f3pFADFerredoxin reductase/0.590
4h4pFADBiphenyl dioxygenase ferredoxin reductase subunit/0.569
4h4zFADBiphenyl dioxygenase ferredoxin reductase subunit/0.563
4h50FADBiphenyl dioxygenase ferredoxin reductase subunit/0.553
4h4yFADBiphenyl dioxygenase ferredoxin reductase subunit/0.548
4h4uFADBiphenyl dioxygenase ferredoxin reductase subunit/0.507
1m6iFADApoptosis-inducing factor 1, mitochondrial1.1.10.501
2yvjFADFerredoxin reductase/0.499
2gr1FADFerredoxin reductase/0.496
4bv6FADApoptosis-inducing factor 1, mitochondrial1.1.10.485
2gr0FADFerredoxin reductase/0.483
5fs6FADApoptosis-inducing factor 1, mitochondrial1.1.10.480
4burFADApoptosis-inducing factor 1, mitochondrial1.1.10.479
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.478
3gd3FADApoptosis-inducing factor 1, mitochondrial1.1.10.476
1gv4FADApoptosis-inducing factor 1, mitochondrial1.1.10.473
4liiFADApoptosis-inducing factor 1, mitochondrial1.1.10.447
3ef6FADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component1.18.1.30.444
5fs8FADApoptosis-inducing factor 1, mitochondrial1.1.10.440