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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4gr1FADGlutathione reductase, mitochondrial1.8.1.7

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4gr1FADGlutathione reductase, mitochondrial1.8.1.71.000
1greFADGlutathione reductase, mitochondrial1.8.1.70.859
1grhFADGlutathione reductase, mitochondrial1.8.1.70.859
1graFADGlutathione reductase, mitochondrial1.8.1.70.847
3grsFADGlutathione reductase, mitochondrial1.8.1.70.846
1grgFADGlutathione reductase, mitochondrial1.8.1.70.838
1grbFADGlutathione reductase, mitochondrial1.8.1.70.725
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.637
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.632
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.628
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.603
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.588
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.579
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.548
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.544
2v6oFADThioredoxin glutathione reductase/0.530
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.524
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.484
2r9zFADGlutathione amide reductase/0.483
2nvkFADThioredoxin reductase 1, mitochondrial1.8.1.90.476
3djgFADGlutathione reductase, mitochondrial1.8.1.70.464
1gerFADGlutathione reductase1.8.1.70.457
2rabFADGlutathione amide reductase/0.455
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.453
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.452
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.444
1febFADTrypanothione reductase1.8.1.120.443
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.440