sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 1.000 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.660 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.646 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.599 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.578 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.570 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.546 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.543 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.538 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.531 | |
| 3eig | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.517 | |
| 1boz | PRD | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.512 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.511 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.502 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.499 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.495 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.484 | |
| 3wv9 | FEG | Hmd co-occurring protein HcgE | / | 0.480 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 1re7 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.478 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.478 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.472 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.471 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.467 | |
| 5ccc | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.466 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.466 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.461 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.458 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.454 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.454 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.454 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.451 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4i1n | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.451 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1rx5 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 2drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.450 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.450 | |
| 1dra | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.449 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.449 | |
| 1dyi | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4x5f | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.447 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.446 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.445 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4i13 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.441 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.440 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.440 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 |