sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4es5 | MGT | Polymerase basic protein 2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4es5 | MGT | Polymerase basic protein 2 | / | 1.000 | |
| 5fmm | MGT | Polymerase basic protein 2 | / | 0.521 | |
| 2vqz | MGT | Polymerase basic protein 2 | / | 0.518 | |
| 4eqk | MGT | Polymerase basic protein 2 | / | 0.516 | |
| 4cb6 | 29R | Polymerase basic protein 2 | / | 0.512 | |
| 4cb4 | MGT | Polymerase basic protein 2 | / | 0.502 | |
| 4nce | MGT | Polymerase basic protein 2 | / | 0.502 | |
| 4cb5 | 93G | Polymerase basic protein 2 | / | 0.490 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.481 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 1f0l | APU | Diphtheria toxin | / | 0.479 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.474 | |
| 4cb7 | 41G | Polymerase basic protein 2 | / | 0.469 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.464 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.462 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.460 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.458 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.458 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.457 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.456 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 3e4a | QIX | Insulin-degrading enzyme | 3.4.24.56 | 0.452 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.452 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.451 | |
| 4j7h | TRH | PCZA361.3 | / | 0.449 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 5cto | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.447 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.446 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 1mdt | APU | Diphtheria toxin | / | 0.445 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.443 | |
| 1k9s | FM1 | Purine nucleoside phosphorylase DeoD-type | / | 0.442 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 4fou | C2E | Uncharacterized protein | / | 0.442 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.441 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 |