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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4em4FADCoenzyme A disulfide reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4em4FADCoenzyme A disulfide reductase/1.000
4eqsFADCoenzyme A disulfide reductase/0.793
4eqwFADCoenzyme A disulfide reductase/0.767
1yqzFADCoenzyme A disulfide reductase/0.756
4emwFADCoenzyme A disulfide reductase/0.538
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.476
1greFADGlutathione reductase, mitochondrial1.8.1.70.475
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.475
1grhFADGlutathione reductase, mitochondrial1.8.1.70.473
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.470
1zk7FADMercuric reductase1.16.1.10.466
1grgFADGlutathione reductase, mitochondrial1.8.1.70.463
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.463
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.460
1joaFADNADH peroxidase1.11.1.10.453
3ic9FADPutative dihydrolipoamide dehydrogenase/0.453
1zx9FADMercuric reductase1.16.1.10.452
1f8wFADNADH peroxidase1.11.1.10.449
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.449
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.448
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.446
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.446
3nt6FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.446
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.446
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.445
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.443
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.442
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.442
4jnqFDAThioredoxin reductase/0.442
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.440
4j56FADThioredoxin reductase 21.8.1.90.440