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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4eftEFTHeat shock protein HSP 90-alpha

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4eftEFTHeat shock protein HSP 90-alpha/1.000
3ft8MOJHeat shock protein HSP 90-alpha/0.667
2qg2A91Heat shock protein HSP 90-alpha/0.637
1uymPU3Heat shock protein HSP 90-beta/0.633
4nh82LCHeat shock protein HSP 90-alpha/0.631
4bqg50QHeat shock protein HSP 90-alpha/0.619
1uyePU9Heat shock protein HSP 90-alpha/0.618
3o0iP54Heat shock protein HSP 90-alpha/0.615
3qdd94MHeat shock protein HSP 90-alpha/0.614
3inxJZCHeat shock protein HSP 90-alpha/0.611
4efuEFUHeat shock protein HSP 90-alpha/0.600
1uy8PU5Heat shock protein HSP 90-alpha/0.597
3d0bSNXHeat shock protein HSP 90-alpha/0.589
1uy9PU6Heat shock protein HSP 90-alpha/0.584
1uykPUXHeat shock protein HSP 90-alpha/0.581
2wi72KLHeat shock protein HSP 90-alpha/0.581
3o6o94MHeat shock protein 83/0.580
2fwyH64Heat shock protein HSP 90-alpha/0.577
2wi4ZZ4Heat shock protein HSP 90-alpha/0.574
1uyhPU0Heat shock protein HSP 90-alpha/0.571
2h55DZ8Heat shock protein HSP 90-alpha/0.571
2ykiYKIHeat shock protein HSP 90-alpha/0.571
3inwJZBHeat shock protein HSP 90-alpha/0.569
1uy7PU4Heat shock protein HSP 90-alpha/0.567
1uy6PU3Heat shock protein HSP 90-alpha/0.565
1uyiPUZHeat shock protein HSP 90-alpha/0.564
2fwzH71Heat shock protein HSP 90-alpha/0.561
1uyfPU1Heat shock protein HSP 90-alpha/0.559
1uydPU8Heat shock protein HSP 90-alpha/0.557
2ykeYKEHeat shock protein HSP 90-alpha/0.555
3hz5Z64Heat shock protein HSP 90-alpha/0.551
4awp99AHeat shock protein HSP 90-alpha/0.544
2ykcYKCHeat shock protein HSP 90-alpha/0.543
2ykjYKJHeat shock protein HSP 90-alpha/0.537
2ykbYKBHeat shock protein HSP 90-alpha/0.530
1uycPU7Heat shock protein HSP 90-alpha/0.527
2yk2YJXHeat shock protein HSP 90-alpha/0.524
4awo99BHeat shock protein HSP 90-alpha/0.523
2yjxYJXHeat shock protein HSP 90-alpha/0.519
2yee2ECHeat shock protein HSP 90-alpha/0.517
3mnrSD1Heat shock protein HSP 90-alpha/0.517
3hz142CHeat shock protein HSP 90-alpha/0.514
4hy6FJ1Heat shock protein HSP 90-alpha/0.513
4awq592Heat shock protein HSP 90-alpha/0.511
3opdHIEHeat shock protein 83/0.503
3hz137DHeat shock protein HSP 90-alpha/0.498
3q5kD1UHeat shock protein 83-1/0.494
2yeiXQIHeat shock protein HSP 90-alpha/0.478
2yk2YJWHeat shock protein HSP 90-alpha/0.468
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.465
2yegXQGHeat shock protein HSP 90-alpha/0.463
4jqlVJ6Heat shock protein HSP 90-alpha/0.462
4bqjXKLHeat shock protein HSP 90-alpha/0.460
3hhu819Heat shock protein HSP 90-alpha/0.459
3ekrPY9Heat shock protein HSP 90-alpha/0.458
2yejXQKHeat shock protein HSP 90-alpha/0.457
3q5lKX2Heat shock protein 83-1/0.457
3vhaVHAHeat shock protein HSP 90-alpha/0.455
2qg0A94Heat shock protein HSP 90-alpha/0.454
1zw9H64ATP-dependent molecular chaperone HSP82/0.453
4z1fH71Heat shock protein 75 kDa, mitochondrial/0.446
1osfKOSHeat shock protein HSP 90-alpha/0.443
2yejZZ3Heat shock protein HSP 90-alpha/0.443
4fcr0TMHeat shock protein HSP 90-alpha/0.440