sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4ea1 | 3RX | Dehydrosqualene synthase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 1.000 | |
| 3tfn | 2CJ | Dehydrosqualene synthase | / | 0.615 | |
| 3acy | 702 | Dehydrosqualene synthase | / | 0.614 | |
| 4ea0 | 651 | Dehydrosqualene synthase | / | 0.592 | |
| 3tfp | 03L | Dehydrosqualene synthase | / | 0.589 | |
| 2zcq | B65 | Dehydrosqualene synthase | / | 0.572 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.571 | |
| 4f6v | ZYM | Dehydrosqualene synthase | / | 0.536 | |
| 1ezf | IN0 | Squalene synthase | 2.5.1.21 | 0.493 | |
| 3acw | 651 | Dehydrosqualene synthase | / | 0.483 | |
| 3vjc | ZGA | Squalene synthase | 2.5.1.21 | 0.483 | |
| 4f6x | ZYL | Dehydrosqualene synthase | / | 0.482 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 3wsb | RWZ | Farnesyltransferase, putative | / | 0.455 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.454 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.448 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.447 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.446 | |
| 3r6p | A8S | Abscisic acid receptor PYL10 | / | 0.446 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.446 | |
| 3q30 | D61 | Squalene synthase | 2.5.1.21 | 0.445 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 5doz | NDP | JamJ | / | 0.443 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.442 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.441 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.441 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.441 |