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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4e2bFMNDehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4e2bFMNDehydrogenase/1.000
4e2dFMNDehydrogenase/0.669
3atyFMNProstaglandin F2a synthase/0.663
3atzFMNProstaglandin F2a synthase/0.631
3f03FMNPentaerythritol tetranitrate reductase/0.571
4jicFMNGTN Reductase/0.571
1h63FMNPentaerythritol tetranitrate reductase/0.554
1h50FMNPentaerythritol tetranitrate reductase/0.549
3p82FMNPentaerythritol tetranitrate reductase/0.541
4rnuFMNNADPH dehydrogenase 11.6.99.10.539
1vyrFMNPentaerythritol tetranitrate reductase/0.535
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.534
1bwlFMNNADPH dehydrogenase 11.6.99.10.531
3p74FMNPentaerythritol tetranitrate reductase/0.531
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.530
2abbFMNPentaerythritol tetranitrate reductase/0.528
1vjiFMN12-oxophytodienoate reductase 11.3.1.420.527
4tmbFMNOld yellow enzyme/0.524
4m5pFMNNADPH dehydrogenase/0.519
2q3rFMN12-oxophytodienoate reductase 11.3.1.420.516
3gkaFMNN-ethylmaleimide reductase/0.515
3hgsFMN12-oxophytodienoate reductase 31.3.1.420.514
3p62FMNPentaerythritol tetranitrate reductase/0.514
4rnvFMNNADPH dehydrogenase 11.6.99.10.512
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.511
3p67FMNPentaerythritol tetranitrate reductase/0.507
3p84FMNPentaerythritol tetranitrate reductase/0.507
1icqFMN12-oxophytodienoate reductase 11.3.1.420.504
3hgrFMN12-oxophytodienoate reductase 11.3.1.420.504
4h6kFMNNADPH dehydrogenase 11.6.99.10.503
1q45FMN12-oxophytodienoate reductase 31.3.1.420.501
1icsFMN12-oxophytodienoate reductase 11.3.1.420.500
3p8jFMNPentaerythritol tetranitrate reductase/0.498
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.498
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.497
1icpFMN12-oxophytodienoate reductase 11.3.1.420.496
4tmcFMNOld yellow enzyme/0.489
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.488
4df2FMNNADPH dehydrogenase/0.488
1bwkFMNNADPH dehydrogenase 11.6.99.10.487
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.486
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.484
1h51FMNPentaerythritol tetranitrate reductase/0.482
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.481
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.480
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.480
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.477
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.475
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.474
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.473
3tjlFMNNADPH dehydrogenase/0.470
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.467
4k7yFMNNADPH dehydrogenase 11.6.99.10.466
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.464
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.460
1oycFMNNADPH dehydrogenase 11.6.99.10.460
4q71FADBifunctional protein PutA/0.460
4r81FMNPredicted NADH dehydrogenase/0.460
3gfbNADL-threonine 3-dehydrogenase/0.459
4rnwFMNNADPH dehydrogenase 11.6.99.10.459
1g6kNADGlucose 1-dehydrogenase1.1.1.470.454
1oyaFMNNADPH dehydrogenase 11.6.99.10.454
4q73FADBifunctional protein PutA/0.451
2f1kNAPPrephenate dehydrogenase/0.450
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.449
3gggNADPrephenate dehydrogenase/0.447
3b70NAPEnoyl reductase LovC10.445
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
4q72FADBifunctional protein PutA/0.445
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.444
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
2xaaNADSecondary alcohol dehydrogenase/0.443
3rudNADUDP-N-acetylglucosamine 4-epimerase/0.443
2ejvNADL-threonine 3-dehydrogenase/0.442
2jn3JN3Fatty acid-binding protein, liver/0.442
3l5lFMNXenobiotic reductase/0.442
4jjiNADAlcohol dehydrogenase class-3/0.442
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.442
1bwsNDPGDP-L-fucose synthase/0.441
1e3eNAIAlcohol dehydrogenase 41.1.1.10.441
1nvtNAPShikimate dehydrogenase (NADP(+))/0.441
2fzwNADAlcohol dehydrogenase class-31.1.1.10.441
4rvgTYDD-mycarose 3-C-methyltransferase/0.441
1x1aSAMC-20 methyltransferase/0.440
3gqvNAPEnoyl reductase LovC10.440
3sz0FADSulfide-quinone reductase/0.440