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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dymIYZActivin receptor type-12.7.11.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dymIYZActivin receptor type-12.7.11.301.000
3mtfA3FActivin receptor type-12.7.11.300.576
4bgg844Activin receptor type-12.7.11.300.551
5e8wSTUTGF-beta receptor type-12.7.11.300.532
3oom507Activin receptor type-12.7.11.300.529
4c02TAKActivin receptor type-12.7.11.300.514
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.503
3gxlQIGTGF-beta receptor type-12.7.11.300.496
2wotZZGTGF-beta receptor type-12.7.11.300.493
3hmm855TGF-beta receptor type-12.7.11.300.492
1rw8580TGF-beta receptor type-12.7.11.300.491
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.490
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.489
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.488
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.485
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.484
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.484
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.479
4hge15VTyrosine-protein kinase JAK2/0.479
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.478
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.478
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.477
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.477
5e92ANPTGF-beta receptor type-22.7.11.300.476
1h1s4SPCyclin-dependent kinase 22.7.11.220.475
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.475
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.473
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.472
1bygSTUTyrosine-protein kinase CSK/0.469
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.467
1vjy460TGF-beta receptor type-12.7.11.300.466
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.466
3uyt0CKCasein kinase I isoform delta2.7.11.10.465
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
4i22IREEpidermal growth factor receptor2.7.10.10.461
4aqc88ATyrosine-protein kinase JAK2/0.460
3uzp0CKCasein kinase I isoform delta2.7.11.10.459
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.459
1u4dDBQActivated CDC42 kinase 1/0.458
3oqkS52Renin3.4.23.150.457
4c61LMMTyrosine-protein kinase JAK2/0.457
5e8xSTUTGF-beta receptor type-12.7.11.300.457
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.456
1g5sI17Cyclin-dependent kinase 22.7.11.220.456
3ddpRC8Cyclin-dependent kinase 22.7.11.220.455
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.455
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.455
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.455
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.455
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.454
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.454
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.453
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.453
4c4jX21Dual specificity protein kinase TTK2.7.12.10.453
4gmy0X5Tyrosine-protein kinase JAK2/0.453
1eh4IC1Casein kinase I homolog 12.7.11.10.452
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.452
4bchT7ZCyclin-dependent kinase 92.7.11.220.452
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.452
4iwd1JCHepatocyte growth factor receptor2.7.10.10.452
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.451
2ojg19AMitogen-activated protein kinase 12.7.11.240.451
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.451
3zh8C58Protein kinase C iota type2.7.11.130.451
4riyADPEpidermal growth factor receptor2.7.10.10.451
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.451
2pvhP19Casein kinase II subunit alpha2.7.11.10.450
3gubGUBDeath-associated protein kinase 12.7.11.10.450
3i60E86Mitogen-activated protein kinase 12.7.11.240.450
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.450
4bfwZVWPantothenate kinase2.7.1.330.450
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
1m2pHNACasein kinase II subunit alpha2.7.11.10.449
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.448
3oroAGSSerine/threonine protein kinase/0.448
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.448
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.447
1zeoC01Peroxisome proliferator-activated receptor gamma/0.447
2iw94SPCyclin-dependent kinase 22.7.11.220.447
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.447
2w05FRTCyclin-dependent kinase 22.7.11.220.447
3ggfGVDSerine/threonine-protein kinase 26/0.447
3mtlFEFCyclin-dependent kinase 162.7.11.220.447
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.447
3zep1NXTyrosine-protein kinase JAK32.7.10.20.447
1py5PY1TGF-beta receptor type-12.7.11.300.446
3pqbVGPPutative oxidoreductase/0.446
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.446
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.446
4kbk1QGCasein kinase I isoform delta2.7.11.10.446
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.445
4bfxZVXPantothenate kinase2.7.1.330.445
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.445
4xgxADPFAD:protein FMN transferase/0.445
5cnnANPEpidermal growth factor receptor2.7.10.10.445
3l9mL9McAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3rk708ZCyclin-dependent kinase 22.7.11.220.444
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.444
1h1r6CPCyclin-dependent kinase 22.7.11.220.443
2b7aIZATyrosine-protein kinase JAK2/0.443
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.443
4eor4SPCyclin-dependent kinase 22.7.11.220.443
4h3qANPMitogen-activated protein kinase 12.7.11.240.443
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.443
2pvlP55Casein kinase II subunit alpha2.7.11.10.442
3dogNNNCyclin-dependent kinase 22.7.11.220.442
3du8553Glycogen synthase kinase-3 beta2.7.11.260.442
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.442
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.442
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.442
2izrBRKCasein kinase I isoform gamma-32.7.11.10.441
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3nwxKVSGag-Pol polyprotein3.4.23.160.441
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.441
4eon1ROCyclin-dependent kinase 22.7.11.220.441
5dp2NAPCurF/0.441
1ykr628Cyclin-dependent kinase 22.7.11.220.440
1zys199Serine/threonine-protein kinase Chk12.7.11.10.440
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.440
2hckQUETyrosine-protein kinase HCK2.7.10.20.440
3dd125DGlycogen phosphorylase, liver form2.4.1.10.440
3l8p0CEAngiopoietin-1 receptor2.7.10.10.440
3nynSGVG protein-coupled receptor kinase 62.7.11.160.440
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.440
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.440
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.440