scPDB - Distribution of Binding site Similarity values of 4dpe entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4dpe	NGH	Stromelysin-1	3.4.24.17

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4dpe	NGH	Stromelysin-1	3.4.24.17	1.000
4ja1	NGH	Stromelysin-1	3.4.24.17	0.735
4g9l	NGH	Stromelysin-1	3.4.24.17	0.704
1utt	CP8	Macrophage metalloelastase	3.4.24.65	0.620
1g05	BBH	Stromelysin-1	3.4.24.17	0.613
1d8f	SPI	Stromelysin-1	3.4.24.17	0.601
3ljg	EEF	Macrophage metalloelastase	3.4.24.65	0.600
2wo8	077	Macrophage metalloelastase	3.4.24.65	0.596
1g4k	HQQ	Stromelysin-1	3.4.24.17	0.591
1bqo	N25	Stromelysin-1	3.4.24.17	0.590
2d1o	FA4	Stromelysin-1	3.4.24.17	0.590
2oxw	ILE_ALA_GLY	Macrophage metalloelastase	3.4.24.65	0.589
3kry	3KR	Collagenase 3	3.4.24	0.588
3zxh	E41	Collagenase 3	3.4.24	0.586
4h76	10B	Macrophage metalloelastase	3.4.24.65	0.586
1g49	111	Stromelysin-1	3.4.24.17	0.585
2ovx	4MR	Matrix metalloproteinase-9	3.4.24.35	0.581
1you	PFD	Collagenase 3	3.4.24	0.579
4gr8	R4C	Macrophage metalloelastase	3.4.24.65	0.576
1b8y	IN7	Stromelysin-1	3.4.24.17	0.574
1d8m	BBH	Stromelysin-1	3.4.24.17	0.571
3o2x	3O2	Collagenase 3	3.4.24	0.571
1d7x	SPC	Stromelysin-1	3.4.24.17	0.570
1caq	DPS	Stromelysin-1	3.4.24.17	0.565
2ow0	6MR	Matrix metalloproteinase-9	3.4.24.35	0.564
2yig	5EL	Collagenase 3	3.4.24	0.563
1hy7	MBS	Stromelysin-1	3.4.24.17	0.561
4gr3	R45	Macrophage metalloelastase	3.4.24.65	0.560
3tsk	QEG	Macrophage metalloelastase	3.4.24.65	0.559
1hv5	RXP	Stromelysin-3	3.4.24	0.556
1sln	INH	Stromelysin-1	3.4.24.17	0.555
1zvx	FIN	Neutrophil collagenase	3.4.24.34	0.554
3i7i	518	Collagenase 3	3.4.24	0.554
3oho	Z79	Stromelysin-1	3.4.24.17	0.554
1ciz	DPS	Stromelysin-1	3.4.24.17	0.552
2d1n	FA4	Collagenase 3	3.4.24	0.550
2ow1	7MR	Matrix metalloproteinase-9	3.4.24.35	0.550
2woa	576	Macrophage metalloelastase	3.4.24.65	0.549
3kec	3KE	Collagenase 3	3.4.24	0.549
3ts4	EEG	Macrophage metalloelastase	3.4.24.65	0.549
4guy	KLJ	Macrophage metalloelastase	3.4.24.65	0.549
3lil	EEA	Macrophage metalloelastase	3.4.24.65	0.547
4i03	L88	Macrophage metalloelastase	3.4.24.65	0.544
2ovz	5MR	Matrix metalloproteinase-9	3.4.24.35	0.543
2hu6	37A	Macrophage metalloelastase	3.4.24.65	0.541
2wo9	068	Macrophage metalloelastase	3.4.24.65	0.539
1b3d	S27	Stromelysin-1	3.4.24.17	0.537
2w0d	CGS	Macrophage metalloelastase	3.4.24.65	0.537
4a7b	3W4	Collagenase 3	3.4.24	0.535
1bzs	BSI	Neutrophil collagenase	3.4.24.34	0.534
1zs0	EIN	Neutrophil collagenase	3.4.24.34	0.533
3i7g	732	Collagenase 3	3.4.24	0.533
4a7b	3W5	Collagenase 3	3.4.24	0.532
3b8z	294	A disintegrin and metalloproteinase with thrombospondin motifs 5	3.4.24	0.529
1rm8	BAT	Matrix metalloproteinase-16	3.4.24	0.528
4gr0	R4B	Macrophage metalloelastase	3.4.24.65	0.526
2wo8	023	Macrophage metalloelastase	3.4.24.65	0.525
2ow2	8MR	Matrix metalloproteinase-9	3.4.24.35	0.524
1ztq	033	Collagenase 3	3.4.24	0.521
2wo9	023	Macrophage metalloelastase	3.4.24.65	0.519
2woa	023	Macrophage metalloelastase	3.4.24.65	0.519
1gkc	NFH	Matrix metalloproteinase-9	3.4.24.35	0.518
3hy7	097	A disintegrin and metalloproteinase with thrombospondin motifs 5	3.4.24	0.518
1biw	S80	Stromelysin-1	3.4.24.17	0.515
1d5j	MM3	Stromelysin-1	3.4.24.17	0.513
1c8t	TR1	Stromelysin-1	3.4.24.17	0.504
1fm1	WAY	Collagenase 3	3.4.24	0.493
2oy2	ILE_ALA_GLY	Neutrophil collagenase	3.4.24.34	0.491
1hov	I52	72 kDa type IV collagenase	3.4.24.24	0.483
1mnc	PLH	Neutrophil collagenase	3.4.24.34	0.483
3aig	0ZC	Snake venom metalloproteinase adamalysin-2	3.4.24.46	0.482
2xs4	ALA_PHE_THR	Karilysin	3.4.24	0.476
3cuk	FAD	D-amino-acid oxidase	1.4.3.3	0.475
2rjp	886	A disintegrin and metalloproteinase with thrombospondin motifs 4	3.4.24.82	0.474
2y6d	TQJ	Matrilysin	3.4.24.23	0.472
1qjf	ACS	Isopenicillin N synthase	1.21.3.1	0.470
4wfr	2AM	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.469
2jih	097	A disintegrin and metalloproteinase with thrombospondin motifs 1	3.4.24	0.468
1qiq	ACC	Isopenicillin N synthase	1.21.3.1	0.466
3e8r	615	Disintegrin and metalloproteinase domain-containing protein 17	3.4.24.86	0.464
1g1a	NAD	dTDP-glucose 4,6-dehydratase	/	0.458
2ix5	FAD	Acyl-coenzyme A oxidase 4, peroxisomal	1.3.3.6	0.457
4wdf	A2P	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.456
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.455
1atl	0QI	Snake venom metalloproteinase atrolysin-D	3.4.24.42	0.453
2g76	NAD	D-3-phosphoglycerate dehydrogenase	1.1.1.95	0.453
2vbp	VB1	Isopenicillin N synthase	1.21.3.1	0.453
2vbd	V10	Isopenicillin N synthase	1.21.3.1	0.452
3cvk	N34	Genome polyprotein	2.7.7.48	0.452
4ih7	1ER	Genome polyprotein	2.7.7.48	0.452
4j0v	1H7	Beta-secretase 1	3.4.23.46	0.452
4zzi	1NS	NAD-dependent protein deacetylase sirtuin-1	3.5.1	0.452
3bg7	FAD	Pyranose 2-oxidase	/	0.451
2yph	QQY	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.450
4ozt	P1A	Ecdysone receptor, putative	/	0.450
2jb4	A14	Isopenicillin N synthase	1.21.3.1	0.449
3dd1	25D	Glycogen phosphorylase, liver form	2.4.1.1	0.449
1iol	EST	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.447
1szg	FNS	Cytochrome b2, mitochondrial	1.1.2.3	0.447
1zxc	IH6	Disintegrin and metalloproteinase domain-containing protein 17	3.4.24.86	0.447
2bu9	HFV	Isopenicillin N synthase	1.21.3.1	0.447
2cvj	FAD	Thioredoxin reductase related protein	/	0.447
3ieu	GDP	GTPase Era	/	0.447
3l0t	INN	Disintegrin and metalloproteinase domain-containing protein 17	3.4.24.86	0.447
4bfz	ZVZ	Pantothenate kinase	2.7.1.33	0.447
1xh6	R94	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.446
2dw0	GM6	Zinc metalloproteinase-disintegrin-like VAP2B	3.4.24	0.446
2hun	NAD	336aa long hypothetical dTDP-glucose 4,6-dehydratase	/	0.446
2ivi	ACW	Isopenicillin N synthase	1.21.3.1	0.446
3h86	AP5	Adenylate kinase	/	0.446
3uyk	0CX	Probable NDP-rhamnosyltransferase	/	0.446
4f1l	0RY	Poly [ADP-ribose] polymerase 14	2.4.2.30	0.446
1p0h	ACO	Mycothiol acetyltransferase	2.3.1.189	0.445
2yq9	2AM	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.445
3hy9	098	A disintegrin and metalloproteinase with thrombospondin motifs 5	3.4.24	0.445
3jzd	NAD	Maleylacetate reductase	/	0.445
3lgp	50X	Disintegrin and metalloproteinase domain-containing protein 17	3.4.24.86	0.445
4dxh	NAJ	Alcohol dehydrogenase E chain	1.1.1.1	0.445
2owf	SAH	Diphthine synthase	/	0.444
3pm9	FAD	Putative oxidoreductase	/	0.444
1dth	BAT	Snake venom metalloproteinase atrolysin-D	3.4.24.42	0.443
1qor	NDP	Quinone oxidoreductase 1	/	0.443
1rm5	NDP	Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic	1.2.1.13	0.443
1xh8	R55	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.443
2cf6	NAP	Cinnamyl alcohol dehydrogenase 5	1.1.1.195	0.443
2fzw	NAD	Alcohol dehydrogenase class-3	1.1.1.1	0.443
3cz7	ACO	Histone acetyltransferase RTT109	2.3.1.48	0.443
3ivg	FG5	Pantothenate synthetase	6.3.2.1	0.443
3uyl	TYD	Probable NDP-rhamnosyltransferase	/	0.443
4rx6	ATP	Nitrogen regulatory PII-like protein	/	0.443
1obn	ASV	Isopenicillin N synthase	1.21.3.1	0.442
2b03	TUD	Phospholipase A2, major isoenzyme	3.1.1.4	0.442
3cvu	FAD	RE11660p	/	0.442
1x1d	SAH	C-20 methyltransferase	/	0.441
2d81	RB3	Poly(3-hydroxybutyrate) depolymerase	/	0.441
4xd2	NAI	Alcohol dehydrogenase E chain	1.1.1.1	0.441
3ayk	CGS	Interstitial collagenase	3.4.24.7	0.440
3bsa	1PD	Genome polyprotein	2.7.7.48	0.440
3ivm	ZPR	Prolyl endopeptidase	/	0.440
4gyy	12V	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	/	0.440