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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dlcUMPDeoxyuridine triphosphatase, putative

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dlcUMPDeoxyuridine triphosphatase, putative/1.000
4dkbDUNDeoxyuridine triphosphatase, putative/0.686
2cjeDUNDUTPase/0.646
2yayDUPDUTPase/0.535
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.472
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.471
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
1o6rR19Squalene--hopene cyclase4.2.1.1290.468
1w29TS06,7-dimethyl-8-ribityllumazine synthase2.5.1.780.464
2w6zL21Biotin carboxylase6.3.4.140.464
2cicDUPDUTPase/0.463
3occDIHPurine nucleoside phosphorylase DeoD-type/0.461
3pgtGBXGlutathione S-transferase P2.5.1.180.461
3h3r14HCollagen type IV alpha-3-binding protein/0.460
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.460
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.459
5irnADPNucleotide binding oligomerization domain containing 2/0.459
1xddAAYIntegrin alpha-L/0.458
4b2gV1NUncharacterized protein/0.458
2xvq9DSSerum albumin/0.457
3up3XCAaceDAF-12/0.456
3bsyACOUDP-N-acetylbacillosamine N-acetyltransferase2.3.1.2030.455
1h35R01Squalene--hopene cyclase4.2.1.1290.454
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
1o6qR17Squalene--hopene cyclase4.2.1.1290.453
1nqxRLP6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.452
4dyn0MRNucleoprotein/0.452
1al8DHPPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.451
1ry0PG2Aldo-keto reductase family 1 member C3/0.450
1txtCAAHMG-CoA synthase/0.450
1ndzFR5Adenosine deaminase3.5.4.40.449
2e94364Geranylgeranyl pyrophosphate synthase/0.449
2po3T4K4-dehydrase/0.449
4lv5ADPRhoptry protein 5B/0.449
13gsSASGlutathione S-transferase P2.5.1.180.448
3zeiAWHO-acetylserine sulfhydrylase/0.448
1umlFR4Adenosine deaminase3.5.4.40.447
1ml6GBXGlutathione S-transferase A22.5.1.180.446
1nqw5YL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
3jszUPGUncharacterized protein/0.446
3rtnRTNBeta-secretase 13.4.23.460.445
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1x8lOXRRetinol dehydratase/0.442
2vi5Y196,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
1wklATPNucleoside diphosphate kinase/0.441
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.441
4c49HCYCorticosteroid-binding globulin/0.441
2c97JCL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440