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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bvaT3Ketimine reductase mu-crystallin1.5.1.25

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bvaT3Ketimine reductase mu-crystallin1.5.1.251.000
2ejvNADL-threonine 3-dehydrogenase/0.472
3eksCY9Actin-5C/0.458
1ppjANYCytochrome b/0.457
2y60M8FIsopenicillin N synthase1.21.3.10.457
1yb5NAPQuinone oxidoreductase1.6.5.50.455
3ad9NADSubunit alpha of sarocosine oxidase/0.454
4qe6JN3Bile acid receptor/0.453
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.451
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.451
4j2wFADKynurenine 3-monooxygenase/0.447
5br7FADUDP-galactopyranose mutase/0.446
1v0jFADUDP-galactopyranose mutase5.4.99.90.444
2z3uCRRCytochrome P450/0.444
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
4u2lSFDCholesterol oxidase1.1.3.60.443
2eixFADNADH-cytochrome b5 reductase/0.442
1uzwCDHIsopenicillin N synthase1.21.3.10.441
2uxoTACHTH-type transcriptional regulator TtgR/0.441
3zkyWT4Isopenicillin N synthase1.21.3.10.441
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
4wq5ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.441
1f8gNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.440
4isk1JYThymidylate synthase/0.440