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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.211.000
2yac937Serine/threonine-protein kinase PLK12.7.11.210.591
2rkuR78Serine/threonine-protein kinase PLK12.7.11.210.545
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.543
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.530
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.528
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.517
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.512
2owb626Serine/threonine-protein kinase PLK12.7.11.210.481
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.463
2in6839Wee1-like protein kinase2.7.10.20.453
2z2w770Wee1-like protein kinase2.7.10.20.451
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.443