sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3zzf | NLG | Protein ARG5,6, mitochondrial | 2.7.2.8 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3zzf | NLG | Protein ARG5,6, mitochondrial | 2.7.2.8 | 1.000 | |
| 3zzh | NLG | Protein ARG5,6, mitochondrial | 2.7.2.8 | 0.581 | |
| 2rd5 | NLG | Acetylglutamate kinase, chloroplastic | 2.7.2.8 | 0.522 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.494 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.490 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.464 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.460 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.460 | |
| 1xag | NAD | 3-dehydroquinate synthase | / | 0.458 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.458 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.457 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.455 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.454 | |
| 2fzw | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.453 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.453 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.449 | |
| 2jcx | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.449 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.449 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.448 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.448 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.447 | |
| 2o4c | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.446 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.446 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.446 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.446 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.445 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.445 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.445 | |
| 4o9k | CMK | Arabinose 5-phosphate isomerase | / | 0.444 | |
| 3c0i | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.442 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.442 | |
| 1hdo | NAP | Flavin reductase (NADPH) | / | 0.441 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.441 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.441 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4i8x | 6P3 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.440 | |
| 4p9d | TMP | Deoxycytidylate deaminase | / | 0.440 |