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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3zze6XPHepatocyte growth factor receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3zze6XPHepatocyte growth factor receptor2.7.10.11.000
4gg70J8Hepatocyte growth factor receptor2.7.10.10.620
4ap7F47Hepatocyte growth factor receptor2.7.10.10.590
4deg0JJHepatocyte growth factor receptor2.7.10.10.571
2wgjVGHHepatocyte growth factor receptor2.7.10.10.553
3zxzKRWHepatocyte growth factor receptor2.7.10.10.544
3a4pDFQHepatocyte growth factor receptor2.7.10.10.528
4gg50J3Hepatocyte growth factor receptor2.7.10.10.513
3zc5W9ZHepatocyte growth factor receptor2.7.10.10.511
4aoi4K0Hepatocyte growth factor receptor2.7.10.10.509
2jedLG8Protein kinase C theta type2.7.11.130.484
4i22IREEpidermal growth factor receptor2.7.10.10.481
4kb81QOCasein kinase I isoform delta2.7.11.10.473
2wkmPFYHepatocyte growth factor receptor2.7.10.10.469
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.460
4dymIYZActivin receptor type-12.7.11.300.458
3uyt0CKCasein kinase I isoform delta2.7.11.10.457
4f650S9Fibroblast growth factor receptor 1/0.457
5e8wSTUTGF-beta receptor type-12.7.11.300.456
1eh4IC1Casein kinase I homolog 12.7.11.10.455
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.455
2d29FADAcyl-CoA dehydrogenase/0.454
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
1rfvADPPyridoxal kinase2.7.1.350.453
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
4j95ACPFibroblast growth factor receptor 2/0.453
4gu610NFocal adhesion kinase 12.7.10.20.452
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.451
3nwq2NCGag-Pol polyprotein3.4.23.160.451
1u54ACPActivated CDC42 kinase 1/0.450
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.450
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.450
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.450
4o2bLOCTubulin beta-2B chain/0.450
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.448
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.448
1bsvNDPGDP-L-fucose synthase/0.447
2b7aIZATyrosine-protein kinase JAK2/0.447
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.447
4hge15VTyrosine-protein kinase JAK2/0.446
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.445
4yuqKS1Calmodulin-like domain protein kinase/0.445
2j4z626Aurora kinase A2.7.11.10.444
2zjwREFCasein kinase II subunit alpha2.7.11.10.444
3nwxKVSGag-Pol polyprotein3.4.23.160.444
4nk92K5Fibroblast growth factor receptor 1/0.444
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.444
1ahiCHO7-alpha-hydroxysteroid dehydrogenase1.1.1.1590.443
1nq7ARLNuclear receptor ROR-beta/0.443
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3lpbNVBTyrosine-protein kinase JAK2/0.443
4aqc88ATyrosine-protein kinase JAK2/0.443
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.443
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.443
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.442
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.442
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.442
4ix6ADPUncharacterized protein/0.442
1bygSTUTyrosine-protein kinase CSK/0.441
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.441
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.441
4tuvCPZCytochrome P450 1191.140.441
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
2xa4AZ5Tyrosine-protein kinase JAK2/0.440
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.440
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.440
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.440
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.440