sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3w2n | ROD | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3w2n | ROD | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 1.000 | |
| 3w1t | WRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.640 | |
| 3w2m | ZRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.576 | |
| 3w1r | MRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.572 | |
| 3w2u | ROU | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.539 | |
| 3w2j | QRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.524 | |
| 3w1x | XRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.499 | |
| 3w23 | 3RO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.498 | |
| 3w1q | YRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.496 | |
| 3w3o | ROE | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.493 | |
| 3w2l | VRO | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.479 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 3u9e | COA | Lmo1369 protein | / | 0.467 | |
| 2ou5 | FMN | Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein | / | 0.466 | |
| 4itm | ATP | Tetraacyldisaccharide 4'-kinase | / | 0.462 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.457 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.456 | |
| 1p31 | EPU | UDP-N-acetylmuramate--L-alanine ligase | 6.3.2.8 | 0.455 | |
| 2i51 | FMN | Pyridoxamine 5'-phosphate oxidase-related, FMN-binding | / | 0.454 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.449 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.448 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.448 | |
| 4jzy | FAD | Cryptochrome-1 | / | 0.448 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.447 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.447 | |
| 4g6g | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.445 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 5bsg | NAP | Pyrroline-5-carboxylate reductase | / | 0.444 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.443 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.443 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.443 | |
| 4jia | 1K3 | Tyrosine-protein kinase JAK2 | / | 0.443 | |
| 5ftf | ADP | TPR domain protein | / | 0.443 | |
| 1hdg | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.442 | |
| 4o0r | X4Z | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.442 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.442 | |
| 4b4d | FAD | Ferredoxin-NADP reductase | / | 0.441 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.441 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.440 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.440 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 |