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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3tgpGNPGTPase HRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3tgpGNPGTPase HRas/1.000
4xvqGNPGTPase HRas/0.666
4hdqGNPRas-related protein Rap-1b/0.621
2rggGNPGTPase HRas/0.620
4xvrGNPGTPase HRas/0.610
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.564
1uadGNPRas-related protein Ral-A/0.561
3pitGNPRas-related protein M-Ras/0.545
2fe4GDPRas-related protein Rab-6B/0.540
2cl6CAGGTPase HRas/0.539
4l9sGDPGTPase HRas/0.536
3kkoGNPRas-related protein M-Ras/0.530
3kkqGDPRas-related protein M-Ras/0.530
1zc4GNPRas-related protein Ral-A/0.525
3qbtGNPRas-related protein Rab-8A/0.525
4lpkGDPGTPase KRas/0.524
4lucGDPGTPase KRas/0.523
1z0aGDPRas-related protein Rab-2A/0.522
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.522
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.522
1kmqGNPTransforming protein RhoA/0.514
1x1rGDPRas-related protein M-Ras/0.514
1cxzGSPTransforming protein RhoA/0.510
3mjhGTPRas-related protein Rab-5A/0.509
4wa7GDPGTPase KRas/0.509
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.507
3cphGDPRas-related protein SEC4/0.507
1lfdGNPGTPase HRas/0.505
3ddcGNPGTPase HRas/0.505
4epwGDPGTPase KRas/0.504
2ce2GDPGTPase HRas/0.503
3lbhGNPGTPase HRas/0.503
2rgeGNPGTPase HRas/0.502
1zc3GNPRas-related protein Ral-A/0.500
1xtrGNPGTP-binding protein Rheb/0.499
1z2aGDPRas-related protein Rab-23/0.498
3i3sGNPGTPase HRas/0.498
4o2rGDPGTP-binding protein Rheb/0.497
3k9lGNPGTPase HRas/0.496
3v4fGNPGTPase HRas/0.495
4l8gGDPGTPase KRas/0.495
3k8yGNPGTPase HRas/0.493
3tsoGNPRas-related protein Rab-25/0.493
4lrwGDPGTPase KRas/0.493
4lv6GDPGTPase KRas/0.493
3oivGNPGTPase HRas/0.491
4q03GDPGTPase KRas/0.491
3oesGNPGTPase RhebL1/0.490
4nyiGNPGTPase HRas/0.490
4nyjGNPGTPase HRas/0.490
4q02GDPGTPase KRas/0.489
3lbnGNPGTPase HRas/0.488
2ic5GDPRas-related C3 botulinum toxin substrate 3/0.486
2gcpGSPRho-related GTP-binding protein RhoC/0.485
4d0lGSPRas-related protein Rab-11A/0.485
4tq9GDPGTPase KRas/0.485
1yu9GNPRas-related protein Rab-4A/0.484
4dsuGDPGTPase KRas/0.484
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.483
4k81GTPGTPase HRas/0.483
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.482
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.482
2q3fGNPRas-related GTP-binding protein D/0.482
2ic5GNPRas-related C3 botulinum toxin substrate 3/0.481
1xtsGTPGTP-binding protein Rheb/0.480
2fg5GNPRas-related protein Rab-31/0.480
3x1zGNPRas-related protein Rap-1b/0.480
4dsnGCPGTPase KRas/0.480
2mscGDPMHC class I alpha chain/0.478
2msdGNPMHC class I alpha chain/0.478
2bmeGNPRas-related protein Rab-4A/0.476
3kz1GSPTransforming protein RhoA/0.476
5c46GSPRas-related protein Rab-11A/0.476
1a2bGSPTransforming protein RhoA/0.475
4dltGNPGTPase HRas/0.475
4uj3GNPRas-related protein Rab-11A/0.475
1gwnGTPRho-related GTP-binding protein RhoE/0.474
3a58GNPGTP-binding protein RHO1/0.474
4qxaGTPRas-related protein Rab-9A/0.474
1zbdGTPRas-related protein Rab-3A/0.473
2rgcGNPGTPase HRas/0.473
1g16GDPRas-related protein SEC4/0.471
4epxGDPGTPase KRas/0.471
4lhwGNPRas-related protein Rab-8A/0.471
4obeGDPGTPase KRas/0.471
1m7bGTPRho-related GTP-binding protein RhoE/0.470
1n6lGTPRas-related protein Rab-5A/0.470
4kvgGTPRas-related protein Rap-1A/0.470
3e5hGNPRas-related protein Rab-28/0.469
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.468
3eg5GNPCell division control protein 42 homolog/0.468
1g17GNPRas-related protein SEC4/0.467
1yzqGNPRas-related protein Rab-6A/0.467
2c5lGTPGTPase HRas/0.466
3vhxGTPADP-ribosylation factor 6/0.466
4ql3GDPGTPase KRas/0.466
4ldjGDPGTPase KRas/0.464
1ky2GNPGTP-binding protein YPT7/0.462
3oiwGNPGTPase HRas/0.462
2gvdGSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.461
3rs4GNPGTPase HRas/0.459
4q71FADBifunctional protein PutA/0.459
4hdoGNPRas-related protein Rap-1b/0.458
1am4GNPCell division control protein 42 homolog/0.456
3x1wGDPRas-related protein Rap-1b/0.456
1oixGDPRas-related protein Rab-11A/0.455
2ok7FADFerredoxin--NADP reductase, apicoplast/0.455
3oiuGNPGTPase HRas/0.454
4gojGNPADP-ribosylation factor-like protein 3/0.454
5hpyGDPTransforming protein RhoA/0.453
1t91GTPRas-related protein Rab-7a/0.452
4g0nGNPGTPase HRas/0.452
3lbiGNPGTPase HRas/0.451
5b2zGNPGTPase HRas/0.451
5difGNPGTP-binding nuclear protein Ran/0.451
3w3zGTPGTP-binding nuclear protein Ran/0.450
4js0GNPCell division control protein 42 homolog/0.450
4dlzGNPGTPase HRas/0.449
2clsGTPRho-related GTP-binding protein Rho6/0.448
3ekuCY9Actin-5C/0.448
4cidANPEH domain-containing protein 2/0.448
1tu3GNPRas-related protein Rab-5A/0.446
3c14GSPGuanine nucleotide-binding protein G(s) subunit alpha isoforms short/0.446
3l8yGNPGTPase HRas/0.446
3bbpGTPRas-related protein Rab-6A/0.445
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.445
4irnFADAnaB/0.444
5dhaGNPGTP-binding nuclear protein Ran/0.444
1e3lNADAlcohol dehydrogenase 41.1.1.10.443
4q72FADBifunctional protein PutA/0.443
1s0xC3SNuclear receptor ROR-alpha/0.442
2qf2GDPPhosphoenolpyruvate carboxykinase, cytosolic [GTP]4.1.1.320.442
4dlxGNPGTPase HRas/0.441
4qi5FADCellobiose dehydrogenase/0.441
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.440
1zd9GDPADP-ribosylation factor-like protein 8A/0.440
2gilGTPRas-related protein Rab-6A/0.440
2uuvFADAlkyldihydroxyacetonephosphate synthase2.5.1.260.440
3tnfGNPRas-related protein Rab-8A/0.440
4xoiGTPTransforming protein RhoA/0.440