sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3t8h | UBS | Thermolysin | 3.4.24.27 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3t8h | UBS | Thermolysin | 3.4.24.27 | 1.000 | |
| 3t8d | UBV | Thermolysin | 3.4.24.27 | 0.964 | |
| 3t74 | UBY | Thermolysin | 3.4.24.27 | 0.863 | |
| 4h57 | 0PJ | Thermolysin | 3.4.24.27 | 0.657 | |
| 6tmn | 0PI | Thermolysin | 3.4.24.27 | 0.655 | |
| 4tmn | 0PK | Thermolysin | 3.4.24.27 | 0.649 | |
| 3t87 | UBZ | Thermolysin | 3.4.24.27 | 0.648 | |
| 4tln | LNO | Thermolysin | 3.4.24.27 | 0.647 | |
| 4d9w | X32 | Thermolysin | 3.4.24.27 | 0.626 | |
| 3t8c | UBW | Thermolysin | 3.4.24.27 | 0.625 | |
| 2tmn | 0FA | Thermolysin | 3.4.24.27 | 0.617 | |
| 4b52 | RDF | Bacillolysin | / | 0.550 | |
| 1qf2 | TI3 | Thermolysin | 3.4.24.27 | 0.524 | |
| 3for | ZNP | Thermolysin | 3.4.24.27 | 0.518 | |
| 3fgd | BYA | Thermolysin | 3.4.24.27 | 0.513 | |
| 4ca5 | 3EF | Angiotensin-converting enzyme | 3.2.1 | 0.498 | |
| 4zr5 | RDF | Neprilysin | / | 0.497 | |
| 4bxk | 1IU | Angiotensin-converting enzyme | 3.2.1 | 0.468 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.466 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.466 | |
| 1c7o | PPG | Hemolysin | / | 0.461 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.460 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.459 | |
| 2oc2 | RX3 | Angiotensin-converting enzyme | 3.2.1 | 0.459 | |
| 3c8a | ARG_ARG_GLY_LEU_NH2 | Botulinum neurotoxin type A | 3.4.24.69 | 0.459 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.458 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.458 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3vx4 | ATP | Putative ABC transporter, ATP-binding protein ComA | / | 0.454 | |
| 4iqg | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.454 | |
| 2c1z | U2F | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.453 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.452 | |
| 2x97 | RX4 | Angiotensin-converting enzyme | 3.4.15.1 | 0.451 | |
| 3bj7 | COA | Diamine acetyltransferase 1 | / | 0.451 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 2ifa | FMN | Uncharacterized protein | / | 0.450 | |
| 2p2j | PRX | Acetyl-coenzyme A synthetase | / | 0.450 | |
| 4brg | GNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.449 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3nxq | RX4 | Angiotensin-converting enzyme | 3.2.1 | 0.447 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.447 | |
| 2igq | SAH | Histone-lysine N-methyltransferase EHMT1 | / | 0.445 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.443 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.441 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.441 | |
| 1xg5 | NAP | Dehydrogenase/reductase SDR family member 11 | / | 0.441 | |
| 3ai2 | NDP | NADPH-sorbose reductase | / | 0.441 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.441 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.441 | |
| 1v25 | ANP | Long-chain-fatty-acid--CoA ligase | 6.2.1.3 | 0.440 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3bb3 | GDP | Translocase of chloroplast 33, chloroplastic | 3.6.5 | 0.440 | |
| 6req | 3CP | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.440 |