scPDB - Distribution of Binding site Similarity values of 3t8c entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3t8c	UBW	Thermolysin	3.4.24.27

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
3t8c	UBW	Thermolysin	3.4.24.27	1.000
3t87	UBZ	Thermolysin	3.4.24.27	0.942
4d9w	X32	Thermolysin	3.4.24.27	0.898
3t74	UBY	Thermolysin	3.4.24.27	0.670
3t8d	UBV	Thermolysin	3.4.24.27	0.664
4h57	0PJ	Thermolysin	3.4.24.27	0.660
6tmn	0PI	Thermolysin	3.4.24.27	0.651
4tmn	0PK	Thermolysin	3.4.24.27	0.636
3t8h	UBS	Thermolysin	3.4.24.27	0.632
2tmn	0FA	Thermolysin	3.4.24.27	0.605
4tln	LNO	Thermolysin	3.4.24.27	0.586
1qf2	TI3	Thermolysin	3.4.24.27	0.562
4b52	RDF	Bacillolysin	/	0.560
3fgd	BYA	Thermolysin	3.4.24.27	0.555
3for	ZNP	Thermolysin	3.4.24.27	0.550
3bj7	COA	Diamine acetyltransferase 1	/	0.472
4ara	C56	Acetylcholinesterase	3.1.1.7	0.470
3f28	S7B	Thermolysin	3.4.24.27	0.469
2get	COK	Pantothenate kinase	2.7.1.33	0.466
2ifa	FMN	Uncharacterized protein	/	0.463
3f3s	NAD	Lambda-crystallin homolog	/	0.463
1h2b	NAJ	NAD-dependent alcohol dehydrogenase	/	0.461
4zr5	RDF	Neprilysin	/	0.458
3ai3	NDP	NADPH-sorbose reductase	/	0.457
1k4m	NAD	Nicotinate-nucleotide adenylyltransferase	2.7.7.18	0.456
4gyy	12V	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit	/	0.456
4eso	NAP	Putative oxidoreductase	/	0.455
2ylr	NAP	Phenylacetone monooxygenase	1.14.13.92	0.453
5f8e	SAH	Possible transcriptional regulatory protein	/	0.452
1mok	FAD	2-oxopropyl-CoM reductase, carboxylating	1.8.1.5	0.449
1v0j	FAD	UDP-galactopyranose mutase	5.4.99.9	0.449
4iv6	FDA	Isovaleryl-CoA dehydrogenase	/	0.449
4pzr	COA	Histone acetyltransferase p300	/	0.449
4wso	NAD	Probable nicotinate-nucleotide adenylyltransferase	/	0.449
5cku	FAD	L-ornithine N(5)-monooxygenase	/	0.449
3lqf	NAD	Galactitol dehydrogenase	/	0.448
3r96	ACO	MccE protein	/	0.448
4dmm	NAP	3-oxoacyl-[acyl-carrier-protein] reductase	/	0.448
2hpv	FMN	FMN-dependent NADH-azoreductase	1.7	0.447
2ojt	UBA	Glutamate receptor ionotropic, kainate 1	/	0.447
3vx4	ATP	Putative ABC transporter, ATP-binding protein ComA	/	0.447
2gev	COK	Pantothenate kinase	2.7.1.33	0.446
2ph6	712	Beta-secretase 1	3.4.23.46	0.446
3d3w	NAP	L-xylulose reductase	1.1.1.10	0.446
4d03	NAP	Phenylacetone monooxygenase	1.14.13.92	0.446
4rvf	TYD	D-mycarose 3-C-methyltransferase	/	0.446
1bdb	NAD	Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	/	0.445
3flk	NAI	Tartrate dehydrogenase/decarboxylase	1.1.1.93	0.445
3h59	H59	Genome polyprotein	2.7.7.48	0.445
4ca5	3EF	Angiotensin-converting enzyme	3.2.1	0.445
1vl8	NAP	Oxidoreductase, short chain dehydrogenase/reductase family	/	0.444
2q2v	NAD	Beta-D-hydroxybutyrate dehydrogenase	/	0.444
3bgx	TMP	Thymidylate synthase	/	0.443
1y5r	C0R	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.442
3mx5	UTP	Nucleoprotein	/	0.442
4rsl	FAD	Fructosyl peptide oxidase	/	0.442
1q84	TZ4	Acetylcholinesterase	3.1.1.7	0.441
1xva	SAM	Glycine N-methyltransferase	2.1.1.20	0.441
2p83	MR0	Beta-secretase 1	3.4.23.46	0.441
2ztm	NAD	D(-)-3-hydroxybutyrate dehydrogenase	/	0.441
4eu5	COA	Succinyl-CoA:acetate CoA-transferase	/	0.441
2fxf	ACO	Diamine acetyltransferase 1	/	0.440
3qtx	X43	Cyclin-dependent kinase 2	2.7.11.22	0.440