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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3t7vSAM3-methylornithine synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3t7vSAM3-methylornithine synthase/1.000
1nzdUPGDNA beta-glucosyltransferase/0.469
4loi1YCStimulator of interferon genes protein/0.468
1nzfUPGDNA beta-glucosyltransferase/0.465
3pjuC2EDiguanylate cyclase/phosphodiesterase/0.460
2yvwEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.459
1szcCNANAD-dependent protein deacetylase HST23.5.10.457
3swqEPUUDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.457
3vcyUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.457
3pjtC2EDiguanylate cyclase/phosphodiesterase/0.456
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.455
3q43D66M1 family aminopeptidase3.4.110.454
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.453
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
3zeiAWHO-acetylserine sulfhydrylase/0.450
3hk1B64Fatty acid-binding protein, adipocyte/0.448
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.447
4r7uUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.447
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4wcxSAMBiotin and thiamin synthesis associated/0.445
1q5dEPBEpothilone C/D epoxidase1.140.443
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.442
3er93ATPoly(A) polymerase catalytic subunit2.7.7.190.441
1ddrMTXDihydrofolate reductase1.5.1.30.440
4kf1HT5Aryldialkylphosphatase3.1.8.10.440