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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3s85LK0Gag-Pol polyprotein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3s85LK0Gag-Pol polyprotein/1.000
3ggxGGXGag-Pol polyprotein/0.585
4kb9G79Protease/0.581
1ec2BEJGag-Pol polyprotein3.4.23.160.576
2pk6O33V-1 protease/0.576
2pk5075Protease/0.573
3a2oKNJGag-Pol polyprotein3.4.23.160.572
3oxxDR7Gag-Pol polyprotein3.4.23.160.572
3ndwRITGag-Pol polyprotein3.4.23.160.570
3el9DR7Gag-Pol polyprotein3.4.23.160.569
1hvjA78Gag-Pol polyprotein/0.567
3zptM8YGag-Pol polyprotein3.4.23.160.567
2uy0HV1Gag-Pol polyprotein3.4.23.160.566
2aquDR7Gag-Pol polyprotein3.4.23.160.564
3kdcJZPGag-Pol polyprotein3.4.23.160.564
2xyfG40Gag-Pol polyprotein/0.563
2qd6065Gag-Pol polyprotein3.4.23.160.562
3ggaGGWGag-Pol polyprotein/0.562
2bqvA1AProtease/0.561
1vijBAYGag-Pol polyprotein/0.560
2cen4AHProtease/0.560
2qnnQN1Gag-Pol polyprotein3.4.23.160.560
2wkz5AHGag-Pol polyprotein/0.560
3em4DR7Gag-Pol polyprotein3.4.23.160.559
2a4fAAUV-1 protease/0.557
2ieo017Protease/0.557
2cem2AHPol protein/0.556
2xyeCXGGag-Pol polyprotein/0.556
3zpsEQMGag-Pol polyprotein3.4.23.160.556
4hdfG52Gag-Pol polyprotein3.4.23.160.556
4rvj478Protease/0.556
1ivp1ZKGag-Pol polyprotein/0.555
1d4yTPVGag-Pol polyprotein3.4.23.160.553
1ec3MS3Gag-Pol polyprotein3.4.23.160.553
1xl5190Gag-Pol polyprotein3.4.23.160.553
2upjU02Gag-Pol polyprotein3.4.23.160.553
3kf03TLGag-Pol polyprotein/0.553
2nmyROCProtease/0.552
1wbk568Pol protein/0.551
1tcxIM1Gag-Pol polyprotein3.4.23.160.550
3tl9ROCGag-Pol polyprotein3.4.23.160.550
3zpuM8BGag-Pol polyprotein3.4.23.160.550
4djoMK5Pol polyprotein/0.550
1vikBAYGag-Pol polyprotein/0.549
2fdd385Pol protein/0.549
2fxeDR7Gag-Pol polyprotein3.4.23.160.549
3dk1G05Gag-Pol polyprotein3.4.23.160.549
2bpv1INGag-Pol polyprotein3.4.23.160.548
3ndtROCGag-Pol polyprotein3.4.23.160.548
3nu4478Gag-Pol polyprotein3.4.23.160.548
1ebzBECGag-Pol polyprotein3.4.23.160.547
3ekp478Gag-Pol polyprotein3.4.23.160.547
3nduROCGag-Pol polyprotein3.4.23.160.547
3nu9478Gag-Pol polyprotein3.4.23.160.547
3vf5031Gag-Pol polyprotein3.4.23.160.547
1ebwBEIGag-Pol polyprotein3.4.23.160.546
2bpz3INGag-Pol polyprotein3.4.23.160.546
3ok9G52Gag-Pol polyprotein3.4.23.160.546
1npa3NHGag-Pol polyprotein3.4.23.160.545
1npwLGZGag-Pol polyprotein3.4.23.160.545
2bpy3INGag-Pol polyprotein3.4.23.160.545
3ndxRITGag-Pol polyprotein3.4.23.160.545
4a4qUX9Pol protein/0.545
4ye3G04Gag-Pol polyprotein3.4.23.160.545
3kfn3TLGag-Pol polyprotein/0.544
4njuTPVProtease/0.544
4njvRITProtease/0.544
1fgc2NCGag-Pol polyprotein3.4.23.160.543
1t7i017Gag-Pol polyprotein3.4.23.160.543
2fxdDR7Pol polyprotein/0.543
3ekwDR7Gag-Pol polyprotein3.4.23.160.543
1w5yBE6Gag-Pol polyprotein3.4.23.160.541
2i4wKGQProtease/0.541
2qd8065Gag-Pol polyprotein3.4.23.160.541
2qnpQN2Gag-Pol polyprotein3.4.23.160.541
3k4vROCGag-Pol polyprotein3.4.23.160.541
1difA85Gag-Pol polyprotein/0.540
1hvsA77Gag-Pol polyprotein/0.540
1hxwRITGag-Pol polyprotein/0.540
2idw017Protease/0.540
3d1yROCGag-Pol polyprotein3.4.23.160.540
2hb3GRLProtease/0.539
3vfb031Gag-Pol polyprotein3.4.23.160.539
1ec0BEDGag-Pol polyprotein3.4.23.160.538
1w5xBE5Gag-Pol polyprotein3.4.23.160.538
2aoe0Q4Gag-Pol polyprotein3.4.23.160.538
2wl05AHGag-Pol polyprotein/0.538
3em6017Gag-Pol polyprotein3.4.23.160.538
2a1eIPFGag-Pol polyprotein3.4.23.160.537
2f8g017Gag-Pol polyprotein3.4.23.160.537
2hc0AB2Protease/0.536
2p3b3TLV-1 PROTEASE protein/0.536
2p3b3TLV-1 protease/0.536
2qhcAB1Protease/0.536
2uxzHI1Gag-Pol polyprotein3.4.23.160.536
3nyg2NCGag-Pol polyprotein3.4.23.160.536
1daz0Q4Gag-Pol polyprotein3.4.23.160.535
1k1u0Q4Gag-Pol polyprotein3.4.23.160.535
3st5G89Gag-Pol polyprotein3.4.23.160.535
1d4jMSCGag-Pol polyprotein3.4.23.160.534
1sbgIM1Gag-Pol polyprotein/0.534
2bpw1INGag-Pol polyprotein3.4.23.160.534
1ec1BEEGag-Pol polyprotein3.4.23.160.533
4hdbG52Gag-Pol polyprotein3.4.23.160.533
1ffi2NCGag-Pol polyprotein3.4.23.160.532
1k2b0Q4Gag-Pol polyprotein3.4.23.160.532
1z1hHBBGag-Pol polyprotein3.4.23.160.532
1d4iBEGGag-Pol polyprotein3.4.23.160.531
2p3d3TLProtease/0.531
3bgbLJGGag-Pol polyprotein3.4.23.160.530
3oxcROCProtease/0.530
3s43478Protease/0.530
1a9mU0EGag-Pol polyprotein/0.529
1bdrIM1Gag-Pol polyprotein3.4.23.160.529
1hsgMK1Gag-Pol polyprotein/0.529
1odw0E8Gag-Pol polyprotein3.4.23.160.529
2cej1AHPol protein/0.529
3hzc2NCProtease/0.529
3jvwDMPGag-Pol polyprotein3.4.23.160.529
3nls016Gag-Pol polyprotein3.4.23.160.529
3saa77FProtease/0.529
1b6pPI7Gag-Pol polyprotein3.4.23.160.528
1hxbROCGag-Pol polyprotein3.4.23.160.528
2r5pMK1Gag-Pol polyprotein/0.528
4djqM86Pol polyprotein/0.528
4njsG08Protease/0.528
1d4kPI8Gag-Pol polyprotein3.4.23.160.527
1dw60Q4Gag-Pol polyprotein3.4.23.160.527
1ebyBEBGag-Pol polyprotein3.4.23.160.527
2f80017Gag-Pol polyprotein3.4.23.160.527
2nnkROCProtease/0.527
3ekqROCGag-Pol polyprotein3.4.23.160.527
3nuo478Gag-Pol polyprotein3.4.23.160.527
3oxv478Gag-Pol polyprotein3.4.23.160.527
4j55031Gag-Pol polyprotein3.4.23.160.527
1fff0Q4Gag-Pol polyprotein3.4.23.160.526
1hshMK1Gag-Pol polyprotein/0.526
1rl8RITGag-Pol polyprotein3.4.23.160.526
2ien017Gag-Pol polyprotein3.4.23.160.526
1b6mPI6Gag-Pol polyprotein3.4.23.160.525
3djkG55Gag-Pol polyprotein3.4.23.160.525
3mxeK54Gag-Pol polyprotein3.4.23.160.525
3nxe2NCProtease/0.525
4a6bQG8Gag-Pol polyprotein3.4.23.160.525
1hviA77Protease/0.524
1iiq0ZRGag-Pol polyprotein3.4.23.160.524
1yt9OISGag-Pol polyprotein/0.524
2avm2NCGag-Pol polyprotein3.4.23.160.524
3jvy017Gag-Pol polyprotein3.4.23.160.524
3jw2017Gag-Pol polyprotein3.4.23.160.524
7upjINUGag-Pol polyprotein3.4.23.160.524
1izhQ50Protease/0.523
1mtrPI6Gag-Pol polyprotein3.4.23.160.523
1muiAB1Protease/0.523
1t3r017Gag-Pol polyprotein3.4.23.160.523
3el1DR7Gag-Pol polyprotein3.4.23.160.523
3i7eDJRGag-Pol polyprotein/0.523
3linE13Protease/0.523
3nwq2NCGag-Pol polyprotein3.4.23.160.523
3cktYDPGag-Pol polyprotein3.4.23.160.522
4njt017Protease/0.522
1fg62NCGag-Pol polyprotein3.4.23.160.521
1g35AHFGag-Pol polyprotein3.4.23.160.521
2f3kRO1Protease/0.521
2fde385Gag-Pol polyprotein3.4.23.160.521
2qci065Gag-Pol polyprotein3.4.23.160.521
3d1z017Gag-Pol polyprotein3.4.23.160.521
3sa755AProtease/0.521
1wbmBLLPol protein/0.520
3kfs3TLGag-Pol polyprotein/0.520
4hdpG52Gag-Pol polyprotein3.4.23.160.520
1sdvMK1Gag-Pol polyprotein3.4.23.160.519
1w5vBE3Gag-Pol polyprotein3.4.23.160.519
1zsr0ZTGag-Pol polyprotein3.4.23.160.519
2avsMK1Gag-Pol polyprotein3.4.23.160.519
3bva2NCGag-Pol polyprotein3.4.23.160.519
3pwrROCGag-Pol polyprotein3.4.23.160.519
1fej2NCGag-Pol polyprotein3.4.23.160.518
1hiv1ZKGag-Pol polyprotein/0.518
2avvMK1Gag-Pol polyprotein3.4.23.160.518
2qak1UNGag-Pol polyprotein3.4.23.160.518
3kddJZQGag-Pol polyprotein3.4.23.160.518
4qgiROCGag-Pol polyprotein3.4.23.160.518
1hvkA79Gag-Pol polyprotein/0.517
2r5q1UNGag-Pol polyprotein/0.517
1hvlA76Gag-Pol polyprotein/0.516
2bb9AKCGag-Pol polyprotein3.4.23.160.516
2i4vDJRV-1 protease/0.516
3bvb017Gag-Pol polyprotein3.4.23.160.516
3i2l2NCProtease/0.516
3s54017Protease/0.516
3vfa031Gag-Pol polyprotein3.4.23.160.516
1d4lPI9Gag-Pol polyprotein3.4.23.160.515
1sdtMK1Gag-Pol polyprotein3.4.23.160.515
2aidTHKGag-Pol polyprotein3.4.23.160.515
2f81017Gag-Pol polyprotein3.4.23.160.515
2rkfAB1Pol protein/0.515
3ttp017Gag-Pol polyprotein3.4.23.160.515
3uhl2NCGag-Pol polyprotein3.4.23.160.515
4k4p3TLGag-Pol polyprotein/0.515
1b6kPI5Gag-Pol polyprotein3.4.23.160.514
1d4hBEHGag-Pol polyprotein3.4.23.160.514
1ohr1UNV-1 PROTEASE protein/0.514
2i4dQFIProtease/0.514
2i4uDJRProtease/0.514
2o4pTPVProtease/0.514
2qi3MZ5Gag-Pol polyprotein/0.514
3dckKVIProtease/0.514
1bai0Q4Gag-Pro polyprotein/0.513
2b7zMK1Gag-Pol polyprotein/0.513
2q5kAB1Protease/0.513
1d4sTPVGag-Pol polyprotein3.4.23.160.512
1hpoUNIGag-Pol polyprotein3.4.23.160.512
2qd7065Gag-Pol polyprotein3.4.23.160.512
2z4o065Gag-Pol polyprotein3.4.23.160.512
3dcrKVSProtease/0.512
3sa9A68Protease/0.512
2hs2017Protease/0.511
2qhzMZ2Gag-Pol polyprotein/0.511
1g2kNM1Gag-Pol polyprotein3.4.23.160.510
1ida0POGag-Pol polyprotein3.4.23.470.510
1meuDMPGag-Pol polyprotein3.4.23.160.510
2i4xKGQProtease/0.510
3i6oGR6Gag-Pol polyprotein3.4.23.160.510
3sa323XProtease/0.510
4dqe017Gag-Pol polyprotein/0.510
1a8g2Z4Gag-Pol polyprotein3.4.23.160.509
1a8k0Q4Gag-Pol polyprotein3.4.23.160.509
3nuj478Gag-Pol polyprotein3.4.23.160.509
3d1xROCGag-Pol polyprotein3.4.23.160.508
3kfr3TLGag-Pol polyprotein/0.508
3nu5478Gag-Pol polyprotein3.4.23.160.508
1ajvNMBGag-Pol polyprotein3.4.23.160.507
1ff02NCGag-Pol polyprotein3.4.23.160.507
2nnpROCProtease/0.507
2qnqQN3Gag-Pol polyprotein3.4.23.160.507
3o9bK2APol polyprotein/0.507
4dqf017Gag-Pol polyprotein/0.507
1a940Q4Gag-Pol polyprotein3.4.23.160.506
1hpxKNIGag-Pol polyprotein/0.506
1npvL27Gag-Pol polyprotein3.4.23.160.506
1sduMK1Gag-Pol polyprotein3.4.23.160.506
1t7kBH0Gag-Pol polyprotein3.4.23.160.506
2bpxMK1Gag-Pol polyprotein3.4.23.160.506
3ekt017Gag-Pol polyprotein3.4.23.160.506
3liqE14Protease/0.506
3mws017Pol protein/0.506
3o9cK20Pol polyprotein/0.506
3oxw017Gag-Pol polyprotein3.4.23.160.506
3qaaG04Gag-Pol polyprotein3.4.23.160.506
3tog079Gag-Pol polyprotein2.7.7.490.506
4a6cQG9Gag-Pol polyprotein3.4.23.160.506
3cyxROCGag-Pol polyprotein3.4.23.160.505
3fx5KNIGag-Pol polyprotein3.4.23.160.505
1iziQ50Gag-Pol polyprotein3.4.23.160.504
1n49RITGag-Pol polyprotein3.4.23.160.504
4dfg0JVGag-Pol polyprotein3.4.23.160.504
4q1y017Gag-Pol polyprotein3.4.23.160.504
1qbrXV6Gag-Pol polyprotein3.4.23.160.503
3o9eA60Pol polyprotein/0.503
1hosPHPGag-Pol polyprotein/0.502
1jld0PPGag-Pol polyprotein/0.502
3bxrDRRGag-Pol polyprotein3.4.23.160.502
3cyw017Gag-Pol polyprotein3.4.23.160.502
3sa6F71Protease/0.502
4gb20LQGag-Pol polyprotein2.7.7.490.502
1fg80Q4Gag-Pol polyprotein3.4.23.160.501
1hihC20Gag-Pol polyprotein/0.501
1idb0DOGag-Pol polyprotein/0.501
1msmJE2Gag-Pol polyprotein3.4.23.160.501
1qbu846Gag-Pol polyprotein3.4.23.160.501
4djr0KJPol polyprotein/0.501
1bwaXV6Gag-Pol polyprotein3.4.23.160.500
1kzkJE2Gag-Pol polyprotein3.4.23.160.500
2q54MU1Protease/0.500
3el4ROCGag-Pol polyprotein3.4.23.160.500
4djpM73Pol polyprotein/0.500
9hvp0E9Gag-Pol polyprotein/0.500
2qi6MZ8Gag-Pol polyprotein/0.499
2z54AB1Gag-Pol polyprotein3.4.23.160.499
3nwxKVSGag-Pol polyprotein3.4.23.160.499
3vf7031Gag-Pol polyprotein3.4.23.160.499
2q3kMUWGag-Pol polyprotein/0.498
2qi7MZ9Gag-Pol polyprotein/0.498
3lzv017Gag-Pol polyprotein3.4.23.160.498
1ajxAH1Gag-Pol polyprotein3.4.23.160.497
1c6x3INProtease/0.497
3nu6478Gag-Pol polyprotein3.4.23.160.497
2pqzG0GGag-Pol polyprotein3.4.23.160.496
2qi5MZ7Gag-Pol polyprotein/0.496
3t3c017Gag-Pol polyprotein3.4.23.160.496
1c70L75Protease/0.495
3ekv478Gag-Pol polyprotein3.4.23.160.495
3sacAF8Protease/0.495
4dqc017Gag-Pol polyprotein/0.495
1z1rHBHGag-Pol polyprotein3.4.23.160.494
2q641UNGag-Pol polyprotein3.4.23.160.494
2r43G3GGag-Pol polyprotein3.4.23.160.494
3sabF78Protease/0.494
1sh9RITGag-Pol polyprotein3.4.23.160.493
1zsf0ZSGag-Pol polyprotein3.4.23.160.493
2r3tG4GGag-Pol polyprotein3.4.23.160.493
3gi4K60Gag-Pol polyprotein/0.493
1qbsDMPGag-Pol polyprotein3.4.23.160.492
3aidARQGag-Pol polyprotein3.4.23.160.492
3bgcLJHGag-Pol polyprotein3.4.23.160.492
3qbfJHGGag-Pol polyprotein3.4.23.160.492
3sa5A69Protease/0.492
3el51UNGag-Pol polyprotein/0.491
3em3478Gag-Pol polyprotein3.4.23.160.491
3qp0NI8Gag-Pol polyprotein3.4.23.160.491
3sa4F72Protease/0.491
1hiiC20Gag-Pol polyprotein/0.490
1mesDMPGag-Pol polyprotein3.4.23.160.490
2bbbHH1Gag-Pol polyprotein3.4.23.160.490
3lixE17Protease/0.490
1c6zROCProtease/0.489
3ekyDR7Gag-Pol polyprotein3.4.23.160.489
1mrwK57Gag-Pol polyprotein3.4.23.160.488
1m0b0ZQGag-Pol polyprotein3.4.23.160.486
2b60RITPol polyprotein/0.486
3o9gF53Gag-Pol polyprotein/0.486
1odyLP1Gag-Pol polyprotein3.4.23.160.485
3s56ROCProtease/0.485
4hegG52Gag-Pol polyprotein3.4.23.160.485
1b6lPI4Gag-Pol polyprotein3.4.23.160.484
3ggu017Gag-Pol polyprotein3.4.23.160.484
3o9fK2DGag-Pol polyprotein/0.484
1bv7XV6Gag-Pol polyprotein3.4.23.160.483
1hvrXK2Gag-Pol polyprotein/0.483
2pyn1UNGag-Pol polyprotein3.4.23.160.483
1c6yMK1Protease/0.482
1ivq0PXGag-Pol polyprotein/0.482
2r38G4GGag-Pol polyprotein3.4.23.160.482
3qn8NI7Gag-Pol polyprotein3.4.23.160.482
3pwm017Gag-Pol polyprotein3.4.23.160.481
3qrsNK8Gag-Pol polyprotein3.4.23.160.481
3ec0GRLGag-Pol polyprotein3.4.23.470.480
3toh079Gag-Pol polyprotein2.7.7.490.480
3d20017Gag-Pol polyprotein3.4.23.160.479
3gi6D78Gag-Pol polyprotein/0.479
3nu3478Gag-Pol polyprotein3.4.23.160.479
4dqb017Gag-Pol polyprotein/0.479
4j5j478Gag-Pol polyprotein3.4.23.160.479
2q631UNGag-Pol polyprotein3.4.23.160.478
4hla017Gag-Pol polyprotein3.4.23.160.478
3ogqAB1Pol polyprotein/0.477
3wsjMK1Protease/0.477
1proA88Gag-Pol polyprotein/0.476
1sguMK1Gag-Pol polyprotein3.4.23.160.476
2pym1UNGag-Pol polyprotein3.4.23.160.476
2qi4MZ6Gag-Pol polyprotein/0.476
4i8zG08Gag-Pol polyprotein3.4.23.160.476
2p3a3TLPol protein/0.475
2pwcG3GGag-Pol polyprotein3.4.23.160.475
3qrmNK7Gag-Pol polyprotein3.4.23.160.475
1sivPSIGag-Pol polyprotein/0.474
3gi5K62Gag-Pol polyprotein/0.474
3lzu017Gag-Pol polyprotein3.4.23.160.473
1bdqIM1Gag-Pol polyprotein3.4.23.160.472
1t7j478Gag-Pol polyprotein3.4.23.160.472
3livE16Protease/0.472
3o9dK19Pol polyprotein/0.472
1qbt146Gag-Pol polyprotein3.4.23.160.471
3litE15Protease/0.471
3o9iA61Gag-Pol polyprotein/0.471
2p3c3TLProtease/0.470
3oy4017Gag-Pol polyprotein3.4.23.160.470
1k6vXN2Gag-Pol polyprotein3.4.23.160.469
3lzs017Gag-Pol polyprotein3.4.23.160.469
1hpv478Gag-Pol polyprotein/0.468
2q55MU0Protease/0.468
2r3wG3GGag-Pol polyprotein3.4.23.160.467
3qroNK9Gag-Pol polyprotein3.4.23.160.467
2hs1017Protease/0.466
3ufnROCGag-Pol polyprotein/0.466
1bv9XV6Gag-Pol polyprotein3.4.23.160.464
2pwrG4GGag-Pol polyprotein3.4.23.160.464
3o9hK2EGag-Pol polyprotein/0.464
1hwr216Gag-Pol polyprotein3.4.23.160.463
3ucb017Gag-Pol polyprotein/0.462
6upjNIUGag-Pol polyprotein/0.462
1msnJE2Gag-Pol polyprotein3.4.23.160.461
3ecg065Gag-Pol polyprotein3.4.23.470.461
4dqh017Gag-Pol polyprotein/0.461
4q1w017Gag-Pol polyprotein3.4.23.160.460
4q1x017Gag-Pol polyprotein3.4.23.160.460
2psuMUUProtease/0.459
2qi1MZ4Gag-Pol polyprotein/0.459
3o9aK14Pol polyprotein/0.459
1hbvGANGag-Pol polyprotein/0.458
3ekx1UNGag-Pol polyprotein3.4.23.160.457
3o99K13Pol polyprotein/0.457
3sa8K83Protease/0.457
3mxdK53Gag-Pol polyprotein3.4.23.160.456
1k2c0Q4Gag-Pol polyprotein3.4.23.160.454
4j54G52Gag-Pol polyprotein3.4.23.160.454
1k6tXN1Gag-Pol polyprotein3.4.23.160.453
2qhyMZ1Gag-Pol polyprotein/0.452
3upjU03Gag-Pol polyprotein/0.452
2fleAIProtease/0.450
2qi0MZ3Gag-Pol polyprotein/0.449
1k6pXN3Gag-Pol polyprotein3.4.23.160.448
1bwb146Gag-Pol polyprotein3.4.23.160.447
1k6cMK1Gag-Pol polyprotein3.4.23.160.447
3tof076Gag-Pol polyprotein2.7.7.490.443
1ebk0Q4Gag-Pol polyprotein3.4.23.160.442
2psvMUVProtease/0.441
3el01UNGag-Pol polyprotein3.4.23.160.441
1metDMPGag-Pol polyprotein3.4.23.160.440
2i0dMUTProtease/0.440