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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/1.000
1xg5NAPDehydrogenase/reductase SDR family member 11/0.593
3l77NJPShort-chain alcohol dehydrogenase/0.572
3tn7NJPShort-chain alcohol dehydrogenase/0.569
1xkqNDPUncharacterized protein/0.561
1ipeNDPTropinone reductase 21.1.1.2360.548
3p19NDPPutative blue fluorescent protein/0.523
4j7uNAPSepiapterin reductase1.1.1.1530.510
1snyNAPLD36273p/0.506
4hwkNAPSepiapterin reductase1.1.1.1530.506
4j7xNAPSepiapterin reductase1.1.1.1530.505
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.498
1x7gNAPPutative ketoacyl reductase1.3.10.498
5idwNAPShort-chain dehydrogenase/reductase SDR/0.497
1ae1NAPTropinone reductase 1/0.496
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.495
4qecNAPElxO/0.495
4bmvNAPShort-chain dehydrogenase/0.494
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.490
2bd0NAPSepiapterin reductase/0.489
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.489
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.488
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.488
1pr9NAPL-xylulose reductase1.1.1.100.486
2yutNAPPutative short-chain oxidoreductase/0.486
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.486
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.483
4qedNAPElxO/0.483
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.483
2jahNDPClavaldehyde dehydrogenase/0.482
4esoNAPPutative oxidoreductase/0.482
1g6kNADGlucose 1-dehydrogenase1.1.1.470.481
3qrwNDPPutative ketoacyl reductase1.3.10.480
1rwbNADGlucose 1-dehydrogenase1.1.1.470.479
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.479
3toxNAPPutative oxidoreductase/0.478
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.478
3d3wNAPL-xylulose reductase1.1.1.100.477
3sjuNDPKeto reductase/0.477
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.477
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.476
1n5dNDPCarbonyl reductase [NADPH] 1/0.475
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.475
1w4zNAPPutative ketoacyl reductase1.3.10.473
1x7hNDPPutative ketoacyl reductase1.3.10.472
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.472
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.472
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.471
1wntNAPL-xylulose reductase1.1.1.100.470
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.470
4dc1NDPPutative ketoacyl reductase1.3.10.470
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.469
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.469
3ai3NDPNADPH-sorbose reductase/0.467
5jlaNADPutative short-chain dehydrogenase/reductase/0.467
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.466
1oaaNAPSepiapterin reductase1.1.1.1530.465
3lqfNADGalactitol dehydrogenase/0.465
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.463
3gy0NAPNAD(P)-dependent oxidoreductase/0.463
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.463
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.462
4gh5NADShort-chain dehydrogenase/reductase SDR/0.462
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.460
4fn4NADShort chain dehydrogenase/0.460
3f1kNAPUncharacterized oxidoreductase YciK10.459
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.458
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.454
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.449
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.448
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.448
1gcoNADGlucose 1-dehydrogenase1.1.1.470.447
2dteNAIGlucose 1-dehydrogenase related protein/0.447
2wdzNADGalactitol dehydrogenase/0.447
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.447
4yagNAIC alpha-dehydrogenase/0.447
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.446
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.444
3pduNAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase/0.444
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.443
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.443
1geeNADGlucose 1-dehydrogenase1.1.1.470.440
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.440
2wsbNADGalactitol dehydrogenase/0.440
3ai2NDPNADPH-sorbose reductase/0.440