sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 1.000 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.567 | |
| 2ev9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.477 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.475 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.468 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.462 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.459 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.458 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.457 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.454 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.452 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.451 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.450 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.447 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.447 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.446 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.445 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.443 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.443 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.443 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.443 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.442 | |
| 2f3e | AXQ | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.442 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3ox4 | NAD | Alcohol dehydrogenase 2 | 1.1.1.1 | 0.442 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.441 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.441 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.441 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.440 |