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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3p7bP7BMitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3p7bP7BMitogen-activated protein kinase 14/1.000
3p5kP5KMitogen-activated protein kinase 14/0.742
3nnuEDBMitogen-activated protein kinase 14/0.587
2yisYISMitogen-activated protein kinase 14/0.586
3hv6R39Mitogen-activated protein kinase 14/0.584
3p7cP7CMitogen-activated protein kinase 14/0.582
3p79P79Mitogen-activated protein kinase 14/0.580
3o8uBMUMitogen-activated protein kinase 14/0.572
1kv2B96Mitogen-activated protein kinase 14/0.558
3uvr06FMitogen-activated protein kinase 14/0.554
3gi3B10Mitogen-activated protein kinase 14/0.550
2puuG2GMitogen-activated protein kinase 14/0.549
3k3jF4CMitogen-activated protein kinase 14/0.546
3hv71AUMitogen-activated protein kinase 14/0.543
3p7aP7AMitogen-activated protein kinase 14/0.541
3nnxEDDMitogen-activated protein kinase 14/0.539
3gcuR48Mitogen-activated protein kinase 14/0.537
3nnwEDDMitogen-activated protein kinase 14/0.532
3p78P78Mitogen-activated protein kinase 14/0.531
3npcB96Mitogen-activated protein kinase 92.7.11.240.520
1kv1BMUMitogen-activated protein kinase 14/0.516
1wbsLI2Mitogen-activated protein kinase 14/0.512
4eh90OQMitogen-activated protein kinase 14/0.505
1wbtWBTMitogen-activated protein kinase 14/0.499
1wbvLI3Mitogen-activated protein kinase 14/0.498
3ugc046Tyrosine-protein kinase JAK2/0.494
3hv4L51Mitogen-activated protein kinase 14/0.492
3lffZ83Mitogen-activated protein kinase 14/0.488
4ehv0SJMitogen-activated protein kinase 14/0.487
3wzeBAXVascular endothelial growth factor receptor 22.7.10.10.485
3gcvSS6Mitogen-activated protein kinase 14/0.484
3cs9NILTyrosine-protein kinase ABL12.7.10.20.479
3vhe42QVascular endothelial growth factor receptor 22.7.10.10.474
2e2b406Tyrosine-protein kinase ABL12.7.10.20.473
1w82L10Mitogen-activated protein kinase 14/0.467
2yiwYIWMitogen-activated protein kinase 14/0.460
1wbnL09Mitogen-activated protein kinase 14/0.458
4jx1CAHCamphor 5-monooxygenase1.14.15.10.456
4u0i0LIMast/stem cell growth factor receptor Kit2.7.10.10.456
3e9319BMitogen-activated protein kinase 14/0.455
2yekEAMBromodomain-containing protein 2/0.452
5hidB1ESerine/threonine-protein kinase B-raf2.7.11.10.452
2hog710Serine/threonine-protein kinase Chk12.7.11.10.450
2v51LABActin, alpha skeletal muscle/0.449
3anlNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.449
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.449
2itpAEEEpidermal growth factor receptor2.7.10.10.448
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.448
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.445
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2znq401Peroxisome proliferator-activated receptor delta/0.445
3gc8B45Mitogen-activated protein kinase 112.7.11.240.443
3gvuSTIAbelson tyrosine-protein kinase 22.7.10.20.443
4nka2K7Fibroblast growth factor receptor 1/0.443
1rdwLARActin, alpha skeletal muscle/0.442
2ath3EAPeroxisome proliferator-activated receptor gamma/0.442
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
1n07FMNRiboflavin kinase2.7.1.260.441
1u3cFADCryptochrome-1/0.441
3d83GK6Mitogen-activated protein kinase 14/0.441
4b1vLABActin, alpha skeletal muscle/0.441
1k6pXN3Gag-Pol polyprotein3.4.23.160.440
3lfnA27Cyclin-dependent kinase 22.7.11.220.440