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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3p19NDPPutative blue fluorescent protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3p19NDPPutative blue fluorescent protein/1.000
4j7xNAPSepiapterin reductase1.1.1.1530.554
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.553
1ae1NAPTropinone reductase 1/0.541
4hwkNAPSepiapterin reductase1.1.1.1530.541
4j7uNAPSepiapterin reductase1.1.1.1530.537
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.534
1ipeNDPTropinone reductase 21.1.1.2360.533
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.533
3tn7NJPShort-chain alcohol dehydrogenase/0.531
3l77NJPShort-chain alcohol dehydrogenase/0.530
1x7gNAPPutative ketoacyl reductase1.3.10.527
1x7hNDPPutative ketoacyl reductase1.3.10.526
3sjuNDPKeto reductase/0.523
1w4zNAPPutative ketoacyl reductase1.3.10.521
3qrwNDPPutative ketoacyl reductase1.3.10.519
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.514
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.512
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.511
3toxNAPPutative oxidoreductase/0.511
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.510
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.508
2jahNDPClavaldehyde dehydrogenase/0.508
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.505
4dc1NDPPutative ketoacyl reductase1.3.10.504
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.504
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.503
1xg5NAPDehydrogenase/reductase SDR family member 11/0.503
1xkqNDPUncharacterized protein/0.503
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.501
2bd0NAPSepiapterin reductase/0.500
5idwNAPShort-chain dehydrogenase/reductase SDR/0.500
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.499
1oaaNAPSepiapterin reductase1.1.1.1530.496
1snyNAPLD36273p/0.494
1n5dNDPCarbonyl reductase [NADPH] 1/0.493
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.488
4qecNAPElxO/0.488
2dteNAIGlucose 1-dehydrogenase related protein/0.487
3d3wNAPL-xylulose reductase1.1.1.100.487
4gh5NADShort-chain dehydrogenase/reductase SDR/0.486
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.485
1gcoNADGlucose 1-dehydrogenase1.1.1.470.485
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.484
5jlaNADPutative short-chain dehydrogenase/reductase/0.484
4qedNAPElxO/0.483
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.481
2yutNAPPutative short-chain oxidoreductase/0.480
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.477
1geeNADGlucose 1-dehydrogenase1.1.1.470.476
2wdzNADGalactitol dehydrogenase/0.476
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.476
1pr9NAPL-xylulose reductase1.1.1.100.475
4bmvNAPShort-chain dehydrogenase/0.475
4fn4NADShort chain dehydrogenase/0.473
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.472
1wntNAPL-xylulose reductase1.1.1.100.472
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.468
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.465
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.465
3ai2NDPNADPH-sorbose reductase/0.465
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.464
3ai3NDPNADPH-sorbose reductase/0.464
3gy0NAPNAD(P)-dependent oxidoreductase/0.464
3ak4NADNADH-dependent quinuclidinone reductase/0.460
3lqfNADGalactitol dehydrogenase/0.460
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.340.459
1g6kNADGlucose 1-dehydrogenase1.1.1.470.458
3f1kNAPUncharacterized oxidoreductase YciK10.458
3vdqNAD3-hydroxybutyrate dehydrogenase/0.457
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.457
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.457
1rwbNADGlucose 1-dehydrogenase1.1.1.470.456
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.455
3wdsNADNADH-dependent quinuclidinone reductase/0.454
4esoNAPPutative oxidoreductase/0.454
4yagNAIC alpha-dehydrogenase/0.452
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.451
1eq2NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.450
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.449
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.449
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.449
3uceNDPDehydrogenase/0.447
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.444
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.443
2yy7NADL-threonine dehydrogenase/0.441
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.441
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.440