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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3oiuGNPGTPase HRas

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3oiuGNPGTPase HRas/1.000
3lbnGNPGTPase HRas/0.635
3v4fGNPGTPase HRas/0.622
3i3sGNPGTPase HRas/0.618
3rs5GNPGTPase HRas/0.617
4dltGNPGTPase HRas/0.617
3oivGNPGTPase HRas/0.614
1zbdGTPRas-related protein Rab-3A/0.604
4nyjGNPGTPase HRas/0.594
2rgcGNPGTPase HRas/0.593
4dlwGNPGTPase HRas/0.593
5b2zGNPGTPase HRas/0.593
3rs7GNPGTPase HRas/0.592
3ddcGNPGTPase HRas/0.591
3kucGDPRas-related protein Rap-1A/0.591
3kkoGNPRas-related protein M-Ras/0.590
4nyiGNPGTPase HRas/0.588
4k81GTPGTPase HRas/0.586
5dhaGNPGTP-binding nuclear protein Ran/0.584
1xtsGTPGTP-binding protein Rheb/0.581
4mitGTPRho-related protein racC/0.581
1zc3GNPRas-related protein Ral-A/0.580
4lhwGNPRas-related protein Rab-8A/0.580
4qxaGTPRas-related protein Rab-9A/0.580
1xtrGNPGTP-binding protein Rheb/0.576
3l8yGNPGTPase HRas/0.575
2c5lGTPGTPase HRas/0.574
3oiwGNPGTPase HRas/0.574
3a6pGTPGTP-binding nuclear protein Ran/0.568
3e5hGNPRas-related protein Rab-28/0.566
3nbzGTPGTP-binding nuclear protein Ran/0.566
2rgbGNPGTPase HRas/0.565
2zetGTPRas-related protein Rab-27B/0.565
2rgeGNPGTPase HRas/0.563
3k8yGNPGTPase HRas/0.562
1zc4GNPRas-related protein Ral-A/0.558
3w3zGTPGTP-binding nuclear protein Ran/0.558
3pitGNPRas-related protein M-Ras/0.557
3rabGNPRas-related protein Rab-3A/0.557
1ibrGNPGTP-binding nuclear protein Ran/0.556
4g0nGNPGTPase HRas/0.556
3lbhGNPGTPase HRas/0.553
4dlxGNPGTPase HRas/0.552
3kudGDPGTPase HRas/0.550
1e96GTPRas-related C3 botulinum toxin substrate 1/0.548
3rs0GNPGTPase HRas/0.548
3bbpGTPRas-related protein Rab-6A/0.547
3lbiGNPGTPase HRas/0.547
4dsnGCPGTPase KRas/0.546
1kmqGNPTransforming protein RhoA/0.545
2gilGTPRas-related protein Rab-6A/0.545
4hdoGNPRas-related protein Rap-1b/0.545
3oesGNPGTPase RhebL1/0.544
3tsoGNPRas-related protein Rab-25/0.544
3x1zGNPRas-related protein Rap-1b/0.544
1t91GTPRas-related protein Rab-7a/0.541
2fe4GDPRas-related protein Rab-6B/0.541
4dlzGNPGTPase HRas/0.541
4o25GTPGTP-binding protein Rheb/0.541
1mh1GNPRas-related C3 botulinum toxin substrate 1/0.539
1g17GNPRas-related protein SEC4/0.538
3a58GNPGTP-binding protein RHO1/0.534
3rslGNPGTPase HRas/0.534
1lfdGNPGTPase HRas/0.529
1yzqGNPRas-related protein Rab-6A/0.527
3sbeGNPRas-related C3 botulinum toxin substrate 1/0.527
4dlvGNPGTPase HRas/0.527
1cxzGSPTransforming protein RhoA/0.526
3lawGNPRas-related protein Rab-7a/0.525
4rkfGNPRas-related protein Rab-3/0.525
5jljGNPGTP-binding nuclear protein Ran/0.525
2qmeGCPRas-related C3 botulinum toxin substrate 3/0.523
4xvrGNPGTPase HRas/0.519
1m7bGTPRho-related GTP-binding protein RhoE/0.517
4uj3GNPRas-related protein Rab-11A/0.517
2gcpGSPRho-related GTP-binding protein RhoC/0.514
3bc1GNPRas-related protein Rab-27A/0.514
3ea5GDPGTP-binding nuclear protein Ran/0.514
5hpyGDPTransforming protein RhoA/0.513
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.512
2w2xGSPRas-related C3 botulinum toxin substrate 2/0.511
2rggGNPGTPase HRas/0.510
3rs4GNPGTPase HRas/0.510
4cymGCPRas-related protein Rab-32/0.510
4ol0GTPGTP-binding nuclear protein Ran/0.509
4kvgGTPRas-related protein Rap-1A/0.507
1uadGNPRas-related protein Ral-A/0.505
3tnfGNPRas-related protein Rab-8A/0.504
4dlsGNPGTPase HRas/0.504
5difGNPGTP-binding nuclear protein Ran/0.503
1zd9GDPADP-ribosylation factor-like protein 8A/0.502
2ffqGSPRas-related protein Rab-6B/0.502
3kz1GSPTransforming protein RhoA/0.502
2ce2GDPGTPase HRas/0.501
1a2bGSPTransforming protein RhoA/0.500
4wa7GDPGTPase KRas/0.500
1ow3GDPTransforming protein RhoA/0.499
1vg8GNPRas-related protein Rab-7a/0.499
4dsoGSPGTPase KRas/0.499
2clsGTPRho-related GTP-binding protein Rho6/0.493
3sbdGNPRas-related C3 botulinum toxin substrate 1/0.493
5c46GSPRas-related protein Rab-11A/0.493
3eg5GNPCell division control protein 42 homolog/0.491
4dxaGSPRas-related protein Rap-1b/0.491
4hdqGNPRas-related protein Rap-1b/0.491
4lucGDPGTPase KRas/0.491
2msdGNPMHC class I alpha chain/0.490
4lpkGDPGTPase KRas/0.490
2bkuGTPGTP-binding nuclear protein Ran/0.489
3tklGTPRas-related protein Rab-1A/0.488
4tq9GDPGTPase KRas/0.488
3tgpGNPGTPase HRas/0.487
2fjuGSPRas-related C3 botulinum toxin substrate 1/0.486
4epxGDPGTPase KRas/0.486
4js0GNPCell division control protein 42 homolog/0.486
4ql3GDPGTPase KRas/0.486
1yu9GNPRas-related protein Rab-4A/0.485
4l9wGNPGTPase HRas/0.485
1oixGDPRas-related protein Rab-11A/0.484
1yhnGTPRas-related protein Rab-7a/0.484
3cphGDPRas-related protein SEC4/0.484
2cl6CAGGTPase HRas/0.483
4q03GDPGTPase KRas/0.481
4xvqGNPGTPase HRas/0.480
4dsuGDPGTPase KRas/0.479
4l9sGDPGTPase HRas/0.478
4uj5GNPRas-related protein Rab-11A/0.478
2xtzGSPGuanine nucleotide-binding protein alpha-1 subunit/0.476
1z0aGDPRas-related protein Rab-2A/0.475
3qbtGNPRas-related protein Rab-8A/0.474
1k5dGNPGTP-binding nuclear protein Ran/0.473
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.473
1s1cGNPTransforming protein RhoA/0.472
4obeGDPGTPase KRas/0.472
3wyfGTPGTP-binding nuclear protein/0.470
4q02GDPGTPase KRas/0.469
3kkqGDPRas-related protein M-Ras/0.468
1z2cGNPRho-related GTP-binding protein RhoC/0.465
4o2lGTPGTP-binding protein Rheb/0.462
4xoiGTPTransforming protein RhoA/0.461
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.460
2d1cNAPIsocitrate dehydrogenase [NADP]1.1.1.420.459
2q3fGNPRas-related GTP-binding protein D/0.459
1mczRMNBenzoylformate decarboxylase4.1.1.70.458
4o2rGDPGTP-binding protein Rheb/0.457
3k9lGNPGTPase HRas/0.456
3vrbFTNSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial/0.456
3vrbFTNCytochrome b-large subunit/0.456
1z2aGDPRas-related protein Rab-23/0.453
1n6lGTPRas-related protein Rab-5A/0.452
3da24MDCarbonic anhydrase 134.2.1.10.451
2p2lGDPRas-related C3 botulinum toxin substrate 1/0.450
2r6gATPMaltose/maltodextrin import ATP-binding protein MalK/0.450
4l8gGDPGTPase KRas/0.450
1gwnGTPRho-related GTP-binding protein RhoE/0.449
4lv6GDPGTPase KRas/0.449
1q12ATPMaltose/maltodextrin import ATP-binding protein MalK/0.448
1g16GDPRas-related protein SEC4/0.447
3th5GNPRas-related C3 botulinum toxin substrate 1/0.447
2z6cFMNPhototropin-12.7.11.10.446
3mjhGTPRas-related protein Rab-5A/0.446
4d0lGSPRas-related protein Rab-11A/0.445
4ead0NPThymidine phosphorylase2.4.2.40.445
2fg5GNPRas-related protein Rab-31/0.444
3wygGTPGTP-binding nuclear protein GSP1/CNR1/0.444
4ldjGDPGTPase KRas/0.444
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.442