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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lqlLDTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3lqlLDTAldose reductase1.1.1.211.000
3lboLDTAldose reductase1.1.1.210.871
3m4h388Aldose reductase1.1.1.210.811
3m64393Aldose reductase1.1.1.210.723
2fz9ZSTAldose reductase1.1.1.210.703
2dv0ZSTAldose reductase1.1.1.210.678
2pdxZSTAldose reductase1.1.1.210.673
1z8962PAldose reductase1.1.1.210.670
1t40ID5Aldose reductase1.1.1.210.646
1z3n3NAAldose reductase1.1.1.210.646
2pdmZSTAldose reductase1.1.1.210.646
4yu153NAldose reductase1.1.1.210.645
2ikj393Aldose reductase1.1.1.210.642
1t41ID5Aldose reductase1.1.1.210.639
4gca2X9Aldose reductase1.1.1.210.639
2hv5ZSTAldose reductase1.1.1.210.635
2ikhLITAldose reductase1.1.1.210.630
2duxZSTAldose reductase1.1.1.210.629
2iki388Aldose reductase1.1.1.210.622
3mb9ZSTAldose reductase1.1.1.210.618
3lz5LDTAldose reductase1.1.1.210.616
2hvnZSTAldose reductase1.1.1.210.615
2i16LDTAldose reductase1.1.1.210.612
2fz8ZSTAldose reductase1.1.1.210.607
2qxwLDTAldose reductase1.1.1.210.597
3m0iZSTAldose reductase1.1.1.210.595
2pdu393Aldose reductase1.1.1.210.593
1pwlBFIAldose reductase1.1.1.210.583
2pdc393Aldose reductase1.1.1.210.576
3lenZSTAldose reductase1.1.1.210.576
3mc5393Aldose reductase1.1.1.210.576
2pdbZSTAldose reductase1.1.1.210.572
3ld5LDTAldose reductase1.1.1.210.571
3ghrLDTAldose reductase1.1.1.210.570
2pdg47DAldose reductase1.1.1.210.568
2pdiZSTAldose reductase1.1.1.210.568
2pd5ZSTAldose reductase1.1.1.210.565
1us0LDTAldose reductase1.1.1.210.561
2pdn47DAldose reductase1.1.1.210.560
1ieiZESAldose reductase1.1.1.210.557
2fzdTOLAldose reductase1.1.1.210.557
2i17LDTAldose reductase1.1.1.210.556
3ghuLDTAldose reductase1.1.1.210.555
2duzZSTAldose reductase1.1.1.210.554
1frbZSTAldose reductase-related protein 2/0.553
2pdh47DAldose reductase1.1.1.210.552
2pdfZSTAldose reductase1.1.1.210.551
2pdp393Aldose reductase1.1.1.210.551
2pdq47DAldose reductase1.1.1.210.543
2hvoZSTAldose reductase1.1.1.210.539
2pzn393Aldose reductase1.1.1.210.539
3g5eQ74Aldose reductase1.1.1.210.537
3t423T4Aldose reductase1.1.1.210.537
3ghtLDTAldose reductase1.1.1.210.527
3ghsLDTAldose reductase1.1.1.210.518
2pdj393Aldose reductase1.1.1.210.516
1zuaTOLAldo-keto reductase family 1 member B101.1.10.502
1el3I84Aldose reductase1.1.1.210.495
1ah3TOLAldose reductase1.1.1.210.487
2pdlTOLAldose reductase1.1.1.210.479
2agtFIDAldose reductase1.1.1.210.478
5liu388Aldo-keto reductase family 1 member B101.1.10.476
2pdwFIDAldose reductase1.1.1.210.470
2aot2PMHistamine N-methyltransferase2.1.1.80.469
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.465
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.463
2pd9FIDAldose reductase1.1.1.210.463
2f2kTGGAldose reductase1.1.1.210.462
2f3815MAldo-keto reductase family 1 member C3/0.460
2pdkSBIAldose reductase1.1.1.210.460
2fzbTOLAldose reductase1.1.1.210.457
1ekoI84Aldose reductase1.1.1.210.455
3s3gTLTAldose reductase1.1.1.210.454
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.452
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.452
2oazI96Methionine aminopeptidase 2/0.449
2iqdLPAAldose reductase1.1.1.210.447
4jtrIZPAldo-keto reductase family 1 member C2/0.447
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
3f3y4OABile salt sulfotransferase2.8.2.140.446
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.446
3uonQNBMuscarinic acetylcholine receptor M2/0.446
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.445
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.444
4hmn16JAldo-keto reductase family 1 member C3/0.444
1ry8RUTAldo-keto reductase family 1 member C3/0.443
2inzOHPAldose reductase1.1.1.210.443
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.443
2aouCQAHistamine N-methyltransferase2.1.1.80.441
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.441
2vcmM11Isopenicillin N synthase1.21.3.10.441
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.441
4u163C0Muscarinic acetylcholine receptor M3/0.441
1odcA8BAcetylcholinesterase3.1.1.70.440
2ckmAA7Acetylcholinesterase3.1.1.70.440
3v35NTIAldose reductase1.1.1.210.440
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.440