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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3l8p0CEAngiopoietin-1 receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3l8p0CEAngiopoietin-1 receptor2.7.10.11.000
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.491
4nka2K7Fibroblast growth factor receptor 1/0.480
3ttjJBIMitogen-activated protein kinase 102.7.11.240.474
2c6eHPMAurora kinase A2.7.11.10.471
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.469
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.469
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.464
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.463
3gxlQIGTGF-beta receptor type-12.7.11.300.462
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.462
1pmn984Mitogen-activated protein kinase 102.7.11.240.461
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.460
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.458
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.458
2w05FRTCyclin-dependent kinase 22.7.11.220.456
5e8wSTUTGF-beta receptor type-12.7.11.300.456
4jia1K3Tyrosine-protein kinase JAK2/0.455
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.454
4nk92K5Fibroblast growth factor receptor 1/0.453
1bygSTUTyrosine-protein kinase CSK/0.450
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.450
2o0uC0MMitogen-activated protein kinase 102.7.11.240.450
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.450
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.450
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.449
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4fob0USALK tyrosine kinase receptor2.7.10.10.449
3hmm855TGF-beta receptor type-12.7.11.300.448
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.448
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.446
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.445
2p33J07Mitogen-activated protein kinase 102.7.11.240.445
4id71G0Activated CDC42 kinase 1/0.445
4jbqVX6Aurora kinase A2.7.11.10.445
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.445
4hvh19RTyrosine-protein kinase JAK32.7.10.20.444
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.444
3w2sW2REpidermal growth factor receptor2.7.10.10.443
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.443
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.443
4gmy0X5Tyrosine-protein kinase JAK2/0.442
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.441
3gubGUBDeath-associated protein kinase 12.7.11.10.440