sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3l0n | S5P | Uridine 5'-monophosphate synthase | 4.1.1.23 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3l0n | S5P | Uridine 5'-monophosphate synthase | 4.1.1.23 | 1.000 | |
| 4hib | 16B | Uridine 5'-monophosphate synthase | 4.1.1.23 | 0.517 | |
| 3uwq | U5P | Orotidine 5'-phosphate decarboxylase | / | 0.516 | |
| 3ewy | U5P | Uridine 5'-monophosphate synthase | 4.1.1.23 | 0.500 | |
| 2yyu | C5P | Orotidine 5'-phosphate decarboxylase | / | 0.477 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.467 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.464 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.463 | |
| 2qo5 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.460 | |
| 1f3p | FAD | Ferredoxin reductase | / | 0.458 | |
| 1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.452 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.451 | |
| 5idw | NAP | Short-chain dehydrogenase/reductase SDR | / | 0.451 | |
| 1q43 | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | / | 0.449 | |
| 2czf | XMP | Orotidine 5'-phosphate decarboxylase | 4.1.1.23 | 0.448 | |
| 5br7 | FAD | UDP-galactopyranose mutase | / | 0.448 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.447 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.447 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.446 | |
| 4rgq | NDP | Glycerol-1-phosphate dehydrogenase [NAD(P)+] | / | 0.445 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.444 | |
| 2fsv | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.444 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 5ej7 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.444 | |
| 1j39 | UPG | DNA beta-glucosyltransferase | / | 0.443 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.443 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.442 | |
| 3k4y | IPE | Isopentenyl phosphate kinase | 2.7.4.26 | 0.442 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.441 | |
| 4n8i | COA | Putative 4-hydroxybutyrate coenzyme A transferase | / | 0.441 | |
| 4o4i | GTP | Tubulin alpha-1B chain | / | 0.441 | |
| 1nzf | UPG | DNA beta-glucosyltransferase | / | 0.440 |