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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3iqhTYR_ASP_ILECysteine synthase2.5.1.47

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3iqhTYR_ASP_ILECysteine synthase2.5.1.471.000
3iqiASN_GLU_ASN_ILECysteine synthase2.5.1.470.682
1y7lASN_LEU_ASN_ILECysteine synthase2.5.1.470.526
3tjzGNPADP-ribosylation factor 1/0.489
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.475
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.474
3k5c0BIBeta-secretase 13.4.23.460.466
4ambDUDPutative glycosyl transferase/0.460
3q43D66M1 family aminopeptidase3.4.110.458
1xe55FEPlasmepsin-23.4.23.390.457
2g20L1ARenin3.4.23.150.455
2gjlFMNNitronate monooxygenase1.13.12.160.454
3b6zCO7Enoyl reductase LovC10.450
3b70NAPEnoyl reductase LovC10.450
1rfuADPPyridoxal kinase2.7.1.350.449
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.449
3hyoADPPyridoxal kinase/0.449
4eb7PLPCysteine desulfurase IscS 2/0.449
4exg916Beta-secretase 13.4.23.460.447
1f8wFADNADH peroxidase1.11.1.10.446
4ipw1G7Mycocyclosin synthase1.14.21.90.441
4xguADPPutative pachytene checkpoint protein 2/0.441
2ahrNAPPyrroline-5-carboxylate reductase/0.440
3fhyATPPyridoxal kinase2.7.1.350.440
3jv7NADSecondary alcohol dehydrogenase/0.440
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.440