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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3idcANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3idcANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.623
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.621
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.614
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.600
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.579
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.575
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.570
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.555
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.554
3idbANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.547
1o6kANPRAC-beta serine/threonine-protein kinase2.7.11.10.546
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.532
1q24ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.529
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.525
4dg3ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.522
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.517
4dh5ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.516
1cdkANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.508
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.495
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
4dh7ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.486
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
3fjqATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.481
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
4hptANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
4ii5ADPCyclin-dependent kinase 22.7.11.220.470
4mb2ATPUncharacterized protein/0.470
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.469
1qmzATPCyclin-dependent kinase 22.7.11.220.468
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
5iqhGNPBifunctional AAC/APH2.3.10.465
1jnkANPMitogen-activated protein kinase 102.7.11.240.463
5bylGCPBifunctional AAC/APH2.3.10.463
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
3ntdCOAFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.461
4xw5ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.460
2cciATPCyclin-dependent kinase 22.7.11.220.457
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
5iqeGNPBifunctional AAC/APH2.3.10.456
2qcsANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4s33ANPMitogen-activated protein kinase 12.7.11.240.455
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.454
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
1u8vFAD4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase/0.453
5cnnANPEpidermal growth factor receptor2.7.10.10.453
2vqdAP2Biotin carboxylase6.3.4.140.452
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4qnyANPMitogen activated protein kinase, putative/0.452
5eowFAD6-hydroxynicotinate 3-monooxygenase1.14.13.1140.452
5iqgGDPBifunctional AAC/APH2.3.10.452
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4s26SAHPhosphomethylpyrimidine synthase, chloroplastic4.1.99.170.451
5e92ANPTGF-beta receptor type-22.7.11.300.451
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.450
3cwkREACellular retinoic acid-binding protein 2/0.450
3o3pGDDGlycosyl transferase, family 2/0.450
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.450
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4eooATPCyclin-dependent kinase 22.7.11.220.448
2wqeADPAurora kinase A2.7.11.10.446
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4bvaT3Ketimine reductase mu-crystallin1.5.1.250.446
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3nt6COAFAD-dependent pyridine nucleotide-disulphide oxidoreductase/0.444
4i3zADPCyclin-dependent kinase 22.7.11.220.444
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.443
1w4aAPCNTPase P4/0.443
2xpvMIYTetracycline repressor protein class D/0.443
3t99ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2/0.443
5cnoANPEpidermal growth factor receptor2.7.10.10.443
1rj9GCPSignal recognition particle receptor FtsY/0.442
4crsAGSSerine/threonine-protein kinase N22.7.11.130.442
5iqiGNPBifunctional AAC/APH2.3.10.442
1esvLARActin, alpha skeletal muscle/0.441
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.441
4fgrADPPhosphoribosylaminoimidazole-succinocarboxamide synthase6.3.2.60.441
4oagADPMitochondrial dynamics protein MID51/0.441
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440