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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.60

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.601.000
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.715
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.657
3hxfBD9Geranylgeranyl transferase type-2 subunit beta2.5.1.600.649
4gts7TPGeranylgeranyl transferase type-2 subunit beta2.5.1.600.642
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.639
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.626
3hxbBD5Geranylgeranyl transferase type-2 subunit beta2.5.1.600.596
4gtt7TQGeranylgeranyl transferase type-2 subunit beta2.5.1.600.540
3hxcBD6Geranylgeranyl transferase type-2 subunit beta2.5.1.600.513
1n4qLYS_CYS_VAL_ILE_LEUGeranylgeranyl transferase type-1 subunit beta2.5.1.590.473
1s64778Geranylgeranyl transferase type-1 subunit beta2.5.1.590.470
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.466
1n4sCYS_VAL_ILE_LEU_GERGeranylgeranyl transferase type-1 subunit beta2.5.1.590.461
3v94WYQPhosphodiesterase/0.460
3n19FNRXenobiotic reductase/0.458
3sfy3FYUncharacterized protein/0.456
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.452
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.448
4gtr7TRProtein farnesyltransferase subunit beta2.5.1.580.445
4kebFOLDihydrofolate reductase1.5.1.30.443
3q7fED2Uncharacterized protein/0.442
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
1pq944BOxysterols receptor LXR-beta/0.441
1h35R01Squalene--hopene cyclase4.2.1.1290.440
1xf0ASDAldo-keto reductase family 1 member C3/0.440